Marc E Key

US Patent:

6727072, Apr 27, 2004

Filed:

May 1, 2001

Appl. No.:

09/846551

Inventors:

Elizabeth O. Spaulding - Santa Barbara CA
Marc E. Key - Ojai CA

Assignee:

Dako Corporation - Carpinteria CA

International Classification:

G01N 3353

US Classification:

435 721, 435 71, 4353877, 435250, 435 23, 435960, 435975, 436501, 436507, 436810, 436822, 436808, 436813, 514 2

Abstract:

A kit containing the reagents necessary for the qualitative or quantitative demonstration of epidermal growth factor receptor (EGFR) in formalin-fixed, paraffin-embedded tissue sections. A immunohistochemical staining procedure is employed which utilizes a primary monoclonal mouse antibody that selectively binds to EGFR. The primary antibodies bound to tissue antigens are detected using a peroxidase labeled polymer that is conjugated with secondary anti-mouse immunoglobulin antibodies. The enzymatic conversion of the subsequently applied chromogen results in formation of a visible reaction product at the site of the EGFR antigen. Following development of the chromogen, specimens may then be counterstained and coverslipped. Results are interpreted using a light microscope or other optical imaging device. The detection system is adapted for both manual and automated staining.

US Patent:

7400983, Jul 15, 2008

Filed:

Dec 19, 2003

Appl. No.:

10/538745

Inventors:

Gordon Feingold - Santa Barbara CA, US
Marc Key - Ojai CA, US
Rosanne Welcher - Ventura CA, US
John Favuzzi - Santa Barbara CA, US

Assignee:

Dako Denmark A/S

International Classification:

G01N 35/00
G01N 35/10

US Classification:

702 31, 702 32, 702 19, 422 67, 436 46, 436 49

Abstract:

A sample processing system () that may be automated and methods are disclosed where samples) () are arranged on a carrier element () and a process operation control system () automatically processes the samples) perhaps robotically with an operationally-influential exteriorly-consequential information monitor () or a data capture element (). Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element () may cause notification of a person at some display () that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

US Patent:

7584019, Sep 1, 2009

Filed:

Sep 16, 2005

Appl. No.:

11/229098

Inventors:

Gordon Alan Feingold - Santa Barbara CA, US
James B. Gilmartin - Los Alamos CA, US
Mark Richard Holbrook - Fort Collins CO, US
John A. Favuzzi - Santa Barbara CA, US
Marc E. Key - Ojai CA, US

Assignee:

Dako Denmark A/S - Glostrup

International Classification:

G06F 19/00

US Classification:

700245, 700 1, 700 95, 700108, 422 63, 422 65, 422100, 422102, 422104, 4352864, 4352873, 4352872, 435 405, 435 4052, 702182, 702 19, 702 31, 436174, 436180, 436518, 436519, 436520, 118419, 118423, 118425

Abstract:

Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.

US Patent:

7593787, Sep 22, 2009

Filed:

Jan 23, 2006

Appl. No.:

11/338522

Inventors:

Gordon Alan Feingold - Santa Barbara CA, US
James B. Gilmartin - Los Alamos CA, US
Mark Richard Holbrook - Fort Collins CO, US
John A. Favuzzi - Santa Barbara CA, US
Marc E. Key - Ojai CA, US

Assignee:

Dako Denmark A/S - Glostrup

International Classification:

G06F 19/00

US Classification:

700245, 700246, 700258, 700259, 702 19, 702 31, 702 32, 73648, 7386401, 7386414, 436 43, 436 44, 436 45, 436 46, 436 49, 435 405, 435 4052, 4352872, 4352873, 4353031

Abstract:

Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus are provided. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.

US Patent:

7603201, Oct 13, 2009

Filed:

Jan 23, 2006

Appl. No.:

11/338524

Inventors:

Gordon Alan Feingold - Santa Barbara CA, US
James B. Gilmartin - Los Alamos CA, US
Mark Richard Holbrook - Fort Collins CO, US
John A. Favuzzi - Santa Barbara CA, US
Marc E. Key - Ojai CA, US

Assignee:

Dako Denmark A/S - Glostrup

International Classification:

G06F 19/00

US Classification:

700245, 700 1, 700 95, 700108, 422 63, 422 65, 4352864, 4352873, 702182

Abstract:

Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.

US Patent:

7648678, Jan 19, 2010

Filed:

Dec 8, 2003

Appl. No.:

10/731316

Inventors:

John Favuzzi - Santa Barbara CA, US
Benno Guggenheimer - Fort Collins CO, US
Jeff Rau - Fort Collins CO, US
Marc Key - Ojai CA, US
Robert Lathrop - San Jose CA, US
Rosanne Welcher - Ventura CA, US

Assignee:

DAKO Denmark A/S - Glostrup

International Classification:

G01N 1/28
G01N 1/30

US Classification:

422 63, 422 65, 436 43, 436 47, 436 49, 436174, 435 405, 4352871, 4352873, 4352883

Abstract:

The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

US Patent:

7758809, Jul 20, 2010

Filed:

Dec 3, 2009

Appl. No.:

12/630665

Inventors:

John Favuzzi - Santa Barbara CA, US
Benno Guggenheimer - Fort Collins CO, US
Jeff Rau - Fort Collins CO, US
Marc Key - Ojai CA, US
Robert Lathrop - San Jose CA, US
Rosanne Welcher - Ventura CA, US

Assignee:

Dako Cytomation Denmark A/S

International Classification:

G01N 1/28
G01N 1/30

US Classification:

422 63, 422 65, 436 43, 436 47, 436 49, 436174, 435 405, 4352871, 4352873, 4352883

Abstract:

The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

US Patent:

7850912, Dec 14, 2010

Filed:

Sep 16, 2005

Appl. No.:

11/227270

Inventors:

John A. Favuzzi - Santa Barbara CA, US
Marc E. Key - Ojai CA, US
Robert L. Lathrop - San Jose CA, US
Gordon A. Feingold - Santa Barbara CA, US
Rosanne Welcher - Ventura CA, US

Assignee:

DAKO Denmark A/S

International Classification:

G01N 33/00

US Classification:

422 63, 422 62, 422 99, 422100, 422102

Abstract:

A method and apparatus for continuous workflow processing of biological samples. In one embodiment, the apparatus includes a probe for dispensing one or more reagents from one or more reagent containers onto one or more biological sample carriers. The method and apparatus includes processing each biological sample according to a respective sequence of protocol steps which may be ordered by a scheduler protocol. The method and apparatus also includes network capability for connectivity with additional equipment for receiving or transmitting pertinent data via the network.