Marc J Kirchmeier

US Patent:

20130295165, Nov 7, 2013

Filed:

Jan 13, 2012

Appl. No.:

13/979322

Inventors:

David E. Anderson - Boston MA, US
Tanvir Ahmed - Nepean, CA
Jasminka Bozic - Ottawa, CA
Marc Kirchmeier - Harleysville PA, US

Assignee:

VARIATION BIOTECHNOLOGIES, INC. - Gatineau QC

International Classification:

A61K 9/127
A61K 47/14
A61K 39/00

US Classification:

424450, 4242041, 4242021, 4242301, 4242321, 4242181, 4242151, 4242121, 4242191

Abstract:

The present disclosure provides compositions and methods useful for treating viral infections. As described herein, the compositions and methods are based on the development of immunogenic compositions that include an attenuated or inactivated virus in combination with a non-ionic surfactant vesicle (NISV).

US Patent:

20130323280, Dec 5, 2013

Filed:

Jan 13, 2012

Appl. No.:

13/979317

Inventors:

David E. Anderson - Boston MA, US
Yvonne Perrie - Solihull, GB
Marc Kirchmeier - Harleysville PA, US
Jitinder Singh Wilkhu - Birmingham, GB

Assignee:

VARIATION BIOTECHNOLOGIES, INC. - Gatineau

International Classification:

A61K 9/10
A61K 39/12
A61K 39/145
A61K 39/00

US Classification:

4242091, 4241841, 4242041, 4242121, 4242191, 4242301, 4242151, 4242321, 4242181

Abstract:

The present disclosure provides methods for preparing vesicles. In one aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding the molten mixture of vesicle-forming lipids to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed, wherein in the step of adding the molten mixture of vesicle forming lipids is at a temperature of less than 120 C. In another aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding an aqueous solution comprising an antigen to the molten mixture of vesicle-forming lipids such that antigen-containing vesicles are formed, wherein the resulting mixture is placed under temperature-controlled conditions of less than 60 C. In yet another aspect, the methods involve providing a solution of vesicle forming lipids and adding the solution of vesicle-forming lipids to an aqueous solution comprising an antigen by injection such that antigen-containing vesicles are formed.

US Patent:

20100216667, Aug 26, 2010

Filed:

Dec 17, 2009

Appl. No.:

12/640481

Inventors:

Brian K. Meyer - New Britain PA, US
Leonardo R. Allain - Lansdale PA, US
David Geer - Eagleville PA, US
Rajiv Mahajan - Lansdale PA, US
David R. Walker - Lansdale PA, US
Marc J. Kirchmeier - Harleysville PA, US

International Classification:

C40B 30/10
G01N 27/26
G01N 30/02
H01J 49/26
G01R 33/44
G01N 21/47

US Classification:

506 12, 204452, 204469, 73 6152, 250282, 324307, 356300

Abstract:

Disclosed is a system or matrix approach for determining compatibility of a pharmaceutically active substance, such as small molecule drug candidate, therapeutic proteins, peptides, vaccines or RNAi, with materials used in the research and development of pharmaceuticals, including plastics, polymers, resins, rubbers, elastomers, glass and steel.