Marc Phillip Porter

US Patent:

7604953, Oct 20, 2009

Filed:

May 30, 2008

Appl. No.:

12/130528

Inventors:

Marc D. Porter - Salt Lake City UT, US
Betsy Jean Yakes - Alexandria VA, US
Robert J. Lipert - Ames IA, US
John P. Bannantine - Ames IA, US

Assignee:

Iowa State University Research Foundation, Inc. - Ames IA
The United States of America as represented by the Department of Agriculture/Cooperative State Research Education and Extension Service (USDA/CSREES) - Washington DC

International Classification:

G01N 33/53
C12Q 1/00
A61K 39/04

US Classification:

435 71, 435 4, 424 91, 424 92, 4241301, 4241631, 4241641, 4241781, 4242341, 4242481

Abstract:

A process of detection of the causative agent of Johne's disease (subsp. ) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows early treatment for Johne's disease in ruminant animals.

US Patent:

20090017562, Jan 15, 2009

Filed:

Mar 7, 2008

Appl. No.:

12/044551

Inventors:

Marc D. Porter - Salt Lake City UT, US
Hye-Young Park - Yongin Si Suji-gu, KR
Robert J. Lipert - Ames IA, US

Assignee:

IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. - Ames IA

International Classification:

G01N 33/544
G01N 33/543

US Classification:

436528, 436518

Abstract:

Raman Active Reagents (ERLs) are developed which use a nanoparticle substrate substantially covered with a mixed monolayer derived from a Raman active reporter molecule and an analyte binding molecule that both bind to the surface of the nanoparticle and thereby avoid the necessity for separate synthesis of a bifunctional linker molecule in making the ERL.

US Patent:

20110070661, Mar 24, 2011

Filed:

Sep 30, 2010

Appl. No.:

12/894693

Inventors:

MARC D. PORTER - Salt Lake City UT, US
JING NI - Sunnyvale CA, US
ROBERT J. LIPERT - AMES IA, US
G. BRENT DAWSON - Greensboro NC, US

Assignee:

IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. - AMES IA

International Classification:

G01N 33/53
G01N 21/00

US Classification:

436501, 436164

Abstract:

The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).

US Patent:

20110070662, Mar 24, 2011

Filed:

Sep 30, 2010

Appl. No.:

12/894810

Inventors:

Marc D. Porter - Salt Lake City UT, US
Jing Ni - Sunnyvale CA, US
Robert J. Lipert - AMES IA, US
G. Brent Dawson - Greensboro NC, US

Assignee:

IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. - AMES IA

International Classification:

G01N 33/53
G01N 21/00

US Classification:

436501, 436164

Abstract:

The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).

US Patent:

20210086102, Mar 25, 2021

Filed:

Sep 19, 2020

Appl. No.:

17/026177

Inventors:

Marc David Porter - Cottonwood Heights UT, US
Robert Joseph Soto - Thousand Oak CA, US
Mark Andrew Hayes - Gilbert AZ, US

Assignee:

University of Utah - Salt Lake City UT

International Classification:

B01D 15/38
B01D 15/22
G01N 30/60

Abstract:

This invention discloses a design a capillary column for use with electrochemically modulated liquid chromatography (EMLC). The capillary design, which results in a marked reduction in the flow of current through the column, enables the use of a two-electrode column construction that overcomes the mechanical and electrical shortfalls of the conventional standard bore design.

US Patent:

20210031166, Feb 4, 2021

Filed:

Jul 29, 2020

Appl. No.:

16/942274

Inventors:

Marc David Porter - Park City UT, US
Jennifer Harnisch Granger - Salt Lake City UT, US
Anton Sergeyevich Klimenko - Salt Lake City UT, US

Assignee:

University of Utah - Salt Lake City UT

International Classification:

B01J 20/02
B01J 20/32

Abstract:

This invention discloses an approach is improve the strength and reproducibility of the signal generated in FTAs using solid-phase microextraction (SPME) through the design of an approach to generate the plasmonically-enhanced signal for SERS, surface-enhanced infrared (SEIRA), and other enhanced spectroscopies. The design incorporates: (1) a particle-particle coupling strategy that is triggered by the selective capture of an analyte to a particle that has been immobilized on a membrane and has been modified to act as a capture substrate; (2) the selective tagging of the captured analyte by a nanoparticle also designed to generate an amplified plasmonic signal upon tagging; and (3) the incorporation of an internal nanoparticle standard to account for fluctuations in flow rates and flow paths. Collectively, these developments improve the accuracy and precision of the analysis as well as the SPME analysis accurately, improving the ease-of-use for a number of different SPME-based measurements, including, for example, those focused on disease markers using immunoassays and a range of other assay formats.

US Patent:

20210031191, Feb 4, 2021

Filed:

Jul 21, 2020

Appl. No.:

16/934102

Inventors:

Marc David Porter - Park City UT, US
Anton Sergeyevich Klimenko - Salt Lake City UT, US
Aleksander Skuratovsky - Salt Lake City UT, US
Jennifer Harnisch Granger - Salt Lake City UT, US

Assignee:

University of Utah - Salt Lake City UT

International Classification:

B01L 3/00

Abstract:

This invention discloses a design of microplates and microarrays to improve utility. The new design constructs a physical flux barrier that limits thermocapillary and other mass transfer contributions to the heterogeneous accumulation of reactant at the surface of a well or array address. The improved control of reactant delivery results in a much more uniform distribution of reactant across an address, thereby improving the accuracy of the measured response.

US Patent:

20210033602, Feb 4, 2021

Filed:

Jul 28, 2020

Appl. No.:

16/940824

Inventors:

Marc David Porter - Park City UT, US
Jennifer Harnisch Granger - Salt Lake City UT, US
Robert Joseph Soto - Thousand Oak CA, US
Lorriane Marie Siperko - Salt Lake City UT, US

Assignee:

University of Utah - Salt Lake City UT

International Classification:

G01N 33/543

Abstract:

This invention discloses an approach regarding the use of solid-phase microextractions (SPMEs) in the analytical, bioanalytical, combinatorial sciences, and all other applicable areas of measurement science. The approach applies to the analysis of exceedingly small volumes of a liquid specimen (10s-100s of μL), and how the concepts of negligible depletion (ND) can be used within the context of tradeoff between extractive (reaction) kinetics, extractive capacity, and sample flow rate as a means to obviate the need to deliver accurately a small volume sample for SPME analysis, improving the ease-of-use for a number of different SPME-based measurements including, for example, disease markers in immunoassays for health care.