Marc E Rutter

US Patent:

6383792, May 7, 2002

Filed:

Dec 3, 1999

Appl. No.:

09/454818

Inventors:

Maxine J. Allen - Encinitas CA
Marc Rutter - San Diego CA
Alan J. Buckler - Cardiff CA

Assignee:

AxyS Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N 914

US Classification:

435195, 530350

Abstract:

The invention features polynucleotides encoding novel GTP-binding polypeptides, hereinafter referred to as RAQ polypeptides; expression vectors comprising a RAQ polynucleotide of the invention; isolated cells comprising a RAQ-encoding vector; a transgenic non-human animal comprising an alteration in a RAQ gene; and the use of RAQ polynucleotides in detecting in an individual the presence of a genetic polymorphism of a RAQ gene. The invention further features novel RAQ polypeptides; monoclonal antibodies specific for RAQ polypeptides; and a method for making RAQ polypeptides.

US Patent:

6399761, Jun 4, 2002

Filed:

Jun 18, 1999

Appl. No.:

09/336643

Inventors:

Andrew P. Miller - San Mateo CA
Ping Hu - Bethesda MD
Mark Edward Curran - Raleigh NC
Marc Rutter - San Diego CA

Assignee:

ICAgen, Inc. - Durham NC

International Classification:

C12N 1512

US Classification:

536 235, 435 691, 4352523, 43525411, 4353201, 435325, 435471, 435 711, 435 712, 530350

Abstract:

Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

US Patent:

20030036648, Feb 20, 2003

Filed:

Apr 11, 2002

Appl. No.:

10/121746

Inventors:

Andrew Miller - San Mateo CA, US
Ping Hu - Bethesda MD, US
Mark Curran - Raleigh NC, US
Marc Rutter - San Diego CA, US
Jian-Yang Wang - San Diego CA, US

Assignee:

ICAgen, Inc. - Durham NC

International Classification:

C07H021/04
C07K014/435
C12P021/02
C12N005/06

US Classification:

536/023500, 530/350000, 435/320100, 435/325000, 435/069100

Abstract:

Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

US Patent:

20050112662, May 26, 2005

Filed:

Oct 29, 2004

Appl. No.:

10/976644

Inventors:

Andrew Miller - San Mateo CA, US
Ping Hu - Bethesda MD, US
Mark Curran - Raleigh NC, US
Marc Rutter - San Diego CA, US

Assignee:

Icagen, Inc. - Durham NC

International Classification:

C12Q001/68
C07H021/04
C07K014/705

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

US Patent:

20050112663, May 26, 2005

Filed:

Oct 29, 2004

Appl. No.:

10/976647

Inventors:

Andrew Miller - San Mateo CA, US
Ping Hu - Bethesda MD, US
Mark Curran - Raleigh NC, US
Marc Rutter - San Diego CA, US
Jian-Yang Wang - San Diego CA, US

Assignee:

Icagen, Inc. - Durham NC

International Classification:

C12Q001/68
C07H021/04
C12N009/22

US Classification:

435006000, 435069100, 435199000, 435320100, 435325000, 536023200

Abstract:

Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

US Patent:

20100273256, Oct 28, 2010

Filed:

Apr 8, 2009

Appl. No.:

12/420791

Inventors:

ANDREW P. MILLER - SAN MATEO CA, US
PING HU - BETHESDA MD, US
MARK EDWARD CURRAN - RALEIGH NC, US
MARC RUTTER - SAN DIEGO CA, US
JIAN-YING WANG - SAN DIEGO CA, US

Assignee:

ICAGEN, INC. - DURHAM NC

International Classification:

C12N 5/07
C12N 15/12
C12N 15/63

US Classification:

435325, 536 235, 4353201

Abstract:

Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

US Patent:

60177101, Jan 25, 2000

Filed:

May 13, 1998

Appl. No.:

9/078317

Inventors:

Maxine J. Allen - Encinitas CA
Marc Rutter - San Diego CA
Alan J. Buckler - Cardiff CA

Assignee:

AxyS Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q 168
C12Q 2106
C12N 1500
C12N 500
C07H 2102

US Classification:

435 6

Abstract:

The invention features polynucleotides encoding novel GTP-binding polypeptides, hereinafter referred to as RAQ polypeptides; expression vectors comprising a RAQ polynucleotide of the invention; isolated cells comprising a RAQ-encoding vector; a transgenic non-human animal comprising an alteration in a RAQ gene; and the use of RAQ polynucleotides in detecting in an individual the presence of a genetic polymorphism of a RAQ gene. The invention further features novel RAQ polypeptides; monoclonal antibodies specific for RAQ polypeptides; and a method for making RAQ polypeptides.