A method of screening a compound for anti-fungal properties comprising the steps of exposing a test compound to a fungal histidine kinase, and determining whether kinase activity is inhibited, wherein inhibition of kinase activity indicates that the compound has anti-fungal properties is disclosed.
- Madison WI, US Huafeng Wang - San Diego CA, US Marcel Wuethrich - Madison WI, US Tristan Theodore Brandhorst - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A61K 39/39 A61K 39/00
Abstract:
A Dectin-2 ligand vaccine adjuvant and a method of making and using the Dectin-2 ligand vaccine adjuvant in a vaccine to immunize a patient are disclosed. Also discloses is a vaccine composition comprising a Bl-Eng2 antigen and methods of using the vaccine composition to immunize a subject against a fungal infection.
Peptide Mhcii Tetramers To Detect Endogenous Calnexin Specific Cd4 T Cells
- Madison WI, US Marcel Wuethrich - Madison WI, US
International Classification:
G01N 33/569
Abstract:
The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
- Madison WI, US Theodore Tristan Brandhorst - Madison WI, US Thomas Sullivan - Madison WI, US Marcel Wuethrich - Madison WI, US
International Classification:
A61K 39/00 C07K 16/14 C07K 14/37
Abstract:
A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
- Madison WI, US Huafeng Wang - Madison WI, US Marcel Wuethrich - Madison WI, US Tristan Theodore Brandhorst - Madison WI, US
International Classification:
A61K 39/39 A61K 39/00
Abstract:
A Dectin-2 ligand vaccine adjuvant and a method of making and using the Dectin-2 ligand vaccine adjuvant in a vaccine to immunize a patient are disclosed. Also discloses is a vaccine composition comprising a Bl-Eng2 antigen and methods of using the vaccine composition to immunize a subject against a fungal infection.
Peptide Mhcii Tetramers To Detect Endogenous Calnexin Specific Cd4 T Cells
- Madison WI, US Marcel Wuethrich - Madison WI, US
International Classification:
G01N 33/569
Abstract:
The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).
- Madison WI, US Theodore Tristan Brandhorst - Madison WI, US Thomas Sullivan - Madison WI, US Marcel Wuethrich - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A61K 39/00
US Classification:
4242741, 530327
Abstract:
A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.