Claude H. Nash - Audubon PA Marcia C. Shearer - Conshohocken PA Kenneth M. Snader - Hatboro PA Joseph R. Valenta - Strafford PA David Cooper - Phoenixville PA
Assignee:
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
C12N 120 C12P 2700 C12P 106 C12R 162
US Classification:
435253
Abstract:
A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragile Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.
Antibiotics Produced By Kibdelosporangium Aridum Shearer Gen. Nov., Sp. Nov. Atcc 39323
Betty A. Bowie - Havertown PA Richard D. Hedde - West Chester PA Thomas O. Lindsey - Coatesville PA David J. Newman - Wayne PA Marcia C. Shearer - Conshohocken PA Robert D. Sitrin - Plymouth Meeting PA Joseph R. Valenta - Strafford PA
Assignee:
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
A61K 3574
US Classification:
424118
Abstract:
A novel antibiotic complex of "vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov. , sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.
Anthracycline Antibiotics Produced By Streptosporangium Fragilis Shearer Sp. Nov. Atcc 31519
Claude H. Nash - Audubon PA Marcia C. Shearer - Conshohocken PA Kenneth M. Snader - Hatboro PA Joseph R. Valenta - Strafford PA David Cooper - Phoenixville PA
Assignee:
SmithKline Corporation - Philadelphia PA
International Classification:
A61K 3500
US Classification:
424119
Abstract:
A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.
John J. Dingerdissen - West Chester PA Rajanikant Mehta - King of Prussia PA Louis J. Nisbet - Rosemont PA Marcia C. Shearer - Conshohocken PA Gail F. Wasserman - Devon PA
Assignee:
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
A61K 3574 C12P 100 C12P 104
US Classification:
530317
Abstract:
A novel subspecies of Kibdelosporangium aridum, subsp. largum (SK&F-AAD-609) produces AAD-216 antibiotics and AAD-609 antibiotics, the ADD-609 antibiotics differing from the AAD-216 antibiotics in presence of glucosamine in the glycolipid radical in place of amino glucuronic acid.
Antibiotics Produced By Kibdelosporangium Aridum Shearer
Betty A. Bowie - Havertown PA David J. Newman - Wayne PA Marcia C. Shearer - Conshohocken PA Robert D. Sitrin - Plymouth Meeting PA Joseph R. Valenta - Strafford PA
Assignee:
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
A61K 3574 C12P 106
US Classification:
424118
Abstract:
A novel antibiotic complex of "Vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov. , sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.
Pure Cultures Of Kibdelsporangium Aridum Shearer Gen. Nov., Sp. Nov. Atcc 39323 And Mutants Thereof
Betty A. Bowie - Havertown PA David J. Newman - Wayne PA Marcia C. Shearer - Conshohocken PA
Assignee:
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
C12N 114 C12R 1645
US Classification:
435254
Abstract:
A novel antibiotic complex of "vancomycin-like" antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov. , sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.