Arnold Hampel - DeKalb IL, US Richard Tritz - DeKalb IL, US Margaret Hicks - Antioch TN, US
International Classification:
C12Q001/68 C07H021/02 C12P019/34
US Classification:
435006000, 435091200, 536023100
Abstract:
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a “hairpin” portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
Arnold E. Hampel - DeKalb IL Richard H. Tritz - DeKalb IL Margaret F. Hicks - Antioch TN
Assignee:
The Board of Regents for Northern Illinois University of DeKalb - DeKalb IL Biotechnology Research and Development Corporation - Peoria IL
International Classification:
C12N 500 C12Q 168 C07H 2104
US Classification:
435375
Abstract:
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
Arnold E. Hampel - DeKalb IL Richard H. Tritz - DeKalb IL Margaret F. Hicks - Antioch TN
Assignee:
The Board of Regents for Northern Illinois University of DeKalb - DeKalb IL Biotechnology Research and Development Corporation - Peoria IL
International Classification:
C12N 1500 C12Q 618 C07H 2104
US Classification:
435375
Abstract:
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
Arnold E. Hampel - DeKalb IL Richard H. Tritz - DeKalb IL Margaret F. Hicks - Antioch TN
Assignee:
The of Regents for Northern Illinois University of DeKalb - DeKalb IL Biotechnology Research and Development Corporation - Peoria IL
International Classification:
C12N 1585 C12Q 168 C07H 2104
US Classification:
435366
Abstract:
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
Mismatched libidos are a source of friction for many couples, often becoming apparent only after the early stages of a relationship when sex tends to be frequent, says Margaret Hicks, a couples counsellor and sex therapist in Toronto. For the spurned party, it can be frustrating and disappointing to