Maria G Fuentes

US Patent:

20120020988, Jan 26, 2012

Filed:

Jul 15, 2011

Appl. No.:

13/184046

Inventors:

JOHANNES AUER - SCHWAIGEN, DE
MARIA FUENTES - WOODCLIFF LAKE NJ, US
GUY GEORGES - HABACH, DE
HUBERT KETTENBERGER - MUENCHEN, DE
HANS-WILLI KRELL - PENZBERG, DE
JENS NIEWOEHNER - MUENCHEN, DE
GEORG TIEFENTHALER - SINDELSDORF, DE

Assignee:

HOFFMANN-LA ROCHE INC. - NUTLEY NJ

International Classification:

A61K 39/395
C12N 15/63
C12N 1/21
C12P 21/06
C12N 5/10
C12N 1/19
C07K 16/28
A61P 37/00

US Classification:

4241721, 5303891, 5303873, 536 2353, 4353201, 435 696, 435325, 435358, 435352, 435365, 4352542, 43525233

Abstract:

An antibody specifically binding to human thymic stromal lymphopoietin receptor (TSLPR), characterized in comprising as heavy chain variable domain CDR regions a CDR1 region of SEQ ID NO:2 or 17, a CDR2 region of SEQ ID NO:3 or 10, and CDR3 region of SEQ ID NO:4, and as light chain variable domain CDR regions a CDR1 region of SEQ ID NO:6 or 12, a CDR2 region of SEQ ID NO:7, 13 or 15, and a CDR3 region of SEQ ID NO:8. is useful for the treatment of immunological diseases.