Maria L Smith

US Patent:

20100040637, Feb 18, 2010

Filed:

Nov 22, 2006

Appl. No.:

12/085482

Inventors:

Karen Van Orden - Gaithersburg MD, US
Maria Leai Smith - Alameda CA, US
Albina Nesterova - Alameda CA, US
Candy Lee - Alameda CA, US
Steve Ruben - Alameda CA, US

International Classification:

A61K 39/395
G01N 33/68
G01N 33/53
A61K 31/7052
C12N 5/00
C12Q 1/02
A61P 35/00

US Classification:

4241721, 436 87, 436501, 514 44 A, 435375, 435 29

Abstract:

Methods and compositions for detecting and treating diseases, especially cancer, and particularly breast, bladder, colon, gastrointestinal, kidney, liver, lung, melanoma, ovary, pancreatic, pharyngeal, prostate cancer and renal, associated with differential expression of prominin-1 (CD133) in disease cells compared to healthy cells. Also provided are antagonists or agonists of prominin-1, and methods for screening agents that modulate the prominin-1 level or activity in vivo or in vitro.

US Patent:

56824882, Oct 28, 1997

Filed:

Apr 3, 1995

Appl. No.:

8/415886

Inventors:

Quynh Dang Gleason - Germantown MD
Christine D. Quay - Cary NC
Eric D. Singer - North Potomac MD
Maria Elena Smith - Plantation FL

Assignee:

International Business Machine Corp. - Armonk NY

International Classification:

G10H 1057

US Classification:

395348

Abstract:

A variable computer icon on a display functions as a single control for a data processing system exercising a complex software function using multiple parameters. As the single control is varied on the display by a user, the response of the complex software function due to automatic parameter changes is varied. Moving the single control in one direction increases the response of the function. Moving the single control in the opposite direction decreases the response of the function. A method is provided for generating settings on the icon to provide smooth, gradual transition with consistent behavior of the function between S. sub. min, the minimum position, to S. sub. max, the maximum position, on the icon. The single control provides ease of use, simplicity in controlling the execution of a complex software function along with a reduction in space consumed by a graphical user interface and the ability to alter the underlying function without any apparent change to the interface.