Maria X Yang

US Patent:

20030054528, Mar 20, 2003

Filed:

Jul 18, 2002

Appl. No.:

10/198343

Inventors:

Bernd Stein - San Diego CA, US
Maria Yang - San Diego CA, US
David Young - San Diego CA, US

Assignee:

Signal Pharmaceuticals, Inc.

International Classification:

C12N009/12
C07H021/04
C12P021/02
C12N005/06
C12N001/21
C12N001/18
C12N015/74

US Classification:

435/194000, 435/069100, 435/320100, 435/252300, 435/254200, 435/325000, 435/348000, 536/023200

Abstract:

Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

US Patent:

20030059881, Mar 27, 2003

Filed:

Jul 16, 2002

Appl. No.:

10/197315

Inventors:

Bernd Stein - San Diego CA, US
Maria Yang - San Diego CA, US
David Young - San Diego CA, US

Assignee:

Signal Pharmaceuticals, Inc.

International Classification:

C12P021/02
C12N005/06
C12N001/21
C07H021/04
C12N009/12
C12N001/18

US Classification:

435/069100, 435/194000, 435/320100, 435/325000, 435/348000, 435/252300, 435/254200, 536/023200

Abstract:

Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.

US Patent:

20030175928, Sep 18, 2003

Filed:

Apr 2, 2003

Appl. No.:

10/406730

Inventors:

Bernd Stein - San Diego CA, US
Maria Yang - San Diego CA, US

Assignee:

Signal Pharmaceuticals, Inc.

International Classification:

C12N009/12
C07H021/04
C12P021/06

US Classification:

435/194000, 435/069100, 435/068100, 435/320100, 435/325000, 536/023200, 424/094500

Abstract:

Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

US Patent:

20040235112, Nov 25, 2004

Filed:

Jun 16, 2004

Appl. No.:

10/870859

Inventors:

Bernd Stein - San Diego CA, US
Maria Yang - San Diego CA, US

Assignee:

Signal Pharmaceuticals, Inc.

International Classification:

C12N009/12
C07H021/04

US Classification:

435/069100, 435/194000, 435/320100, 435/325000, 530/388260, 536/023200

Abstract:

Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

US Patent:

20050255094, Nov 17, 2005

Filed:

Dec 3, 2004

Appl. No.:

11/004789

Inventors:

Bernd Stein - San Diego CA, US
Maria Yang - San Diego CA, US

International Classification:

A61K038/48
C07H021/04
C12P021/06
C12N009/12

US Classification:

424094500, 435069100, 435194000, 435320100, 435325000, 536023200

Abstract:

Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

US Patent:

20060110799, May 25, 2006

Filed:

Jan 5, 2006

Appl. No.:

11/327047

Inventors:

Bernd Stein - San Diego CA, US
Maria Yang - San Diego CA, US

International Classification:

C12P 21/06
C07H 21/04
C12N 9/12

US Classification:

435069100, 435194000, 435320100, 435325000, 536023200

Abstract:

Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

US Patent:

20220339280, Oct 27, 2022

Filed:

Apr 22, 2022

Appl. No.:

17/726952

Inventors:

- Plymouth Meeting PA, US
Stephanie Ramos - Santee CA, US
Trevor Smith - San Diego CA, US
Maria Yang - San Diego CA, US
Richa Kalia - San Diego CA, US
Kate Broderick - San Diego CA, US

International Classification:

A61K 39/215
A61P 37/04

Abstract:

Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject.