Marianna A Busch

US Patent:

7191070, Mar 13, 2007

Filed:

Dec 3, 2004

Appl. No.:

11/004597

Inventors:

Kenneth W. Busch - Waco TX, US
Isabel Maya P. Swamidoss - TamiNadu, IN
Sayo Fakayode - Waco TX, US
Marianna Busch - Waco TX, US

Assignee:

Baylor University - Waco TX

International Classification:

G01N 31/00

US Classification:

702 22, 702 23

Abstract:

A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.

US Patent:

8026483, Sep 27, 2011

Filed:

Oct 11, 2006

Appl. No.:

12/083283

Inventors:

Kenneth W. Busch - Waco TX, US
Dennis H. Rabbe - Crawford TX, US
Marianna Busch - Waco TX, US

Assignee:

Baylor University - Waco TX

International Classification:

G01N 21/21

US Classification:

2503381, 2503361, 250372, 356 51, 356432

Abstract:

A method for determining sugar concentration using spectropolarimetry and multivariate regression modeling A set of fixed polarizers are used in association with a spectrometer, which enables the measurement of optical rotation as absorbance values over a range of wavelengths. The adverse effects of color within the samples is corrected by measuring a background level of absorbance that is not due to optical rotation and using this as a baseline. A regression model is then developed for predicting sugar concentration in unknown samples. This method is effective even if the sample is colored.

US Patent:

8189188, May 29, 2012

Filed:

Oct 6, 2006

Appl. No.:

12/083163

Inventors:

Kenneth W. Busch - Waco TX, US
Jemina Rose Ingle - Lawrence KS, US
Marianna Busch - Waco TX, US

Assignee:

Baylor University - Waco TX

International Classification:

G01J 3/00

US Classification:

356300

Abstract:

A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. In this strategy, the concentration of the chiral compound does not have to be fixed or known.

US Patent:

8190551, May 29, 2012

Filed:

Oct 11, 2006

Appl. No.:

12/083282

Inventors:

Kenneth W. Busch - Waco TX, US
Christopher B. Davis - Live Oak TX, US
Marianna Busch - Waco TX, US

Assignee:

Baylor University - Waco TX

International Classification:

G06F 17/00
G06N 7/04

US Classification:

706 54

Abstract:

A method for classifying textile samples and unknown fabrics into known categories using spectroscopy, chemometric modeling, and soft independent modeling of class analogies (“SIMCA”). The method involves collecting spectral data, preferably diffuse near infrared reflectance data, for a library of known fabric samples, creating a database of principal component analyses for each type of fabric, and using SIMCA to classify an unknown fabric sample according to the database.

US Patent:

20110045598, Feb 24, 2011

Filed:

Oct 17, 2008

Appl. No.:

12/738245

Inventors:

Kenneth W. Busch - Waco TX, US
Selorm Modzabi - Waco TX, US
Marianna Busch - Waco TX, US

International Classification:

G01N 21/00
G06F 19/00

US Classification:

436 89, 702 19, 436164

Abstract:

A strategy, or method, for the quantitative determination of enantiomeric purity that combines lin situ enantiomer diastereomerization', spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-I”) regression. The PLS-I regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. In this strategy, the guest-host complexation utilizes improved chiral selector molecules, including chiral amines and chiral alcohols such as phenylethylamine and 1,2-propanediol, that form ion pairs or covalent bonds with the chiral analytes.

US Patent:

56963785, Dec 9, 1997

Filed:

Mar 20, 1996

Appl. No.:

8/618758

Inventors:

Kenneth W. Busch - Waco TX
Arvie J. Kuehn - Waco TX
Marianna A. Busch - Waco TX

Assignee:

Baylor University - Waco TX

International Classification:

G01N 2172
G01N 2135

US Classification:

25033912

Abstract:

A method and apparatus for quantitatively determining chlorine content and fractional abundance of chlorine isotopes in unknown samples. When using this method and apparatus to determine chlorine content, isotope dilution principles may be employed. Chlorine isotopes used for diluting an unknown sample may be. sup. 35 Cl or. sup. 37 Cl, and relative isotope content in the diluted mixture may be measured using infrared spectrometry.

US Patent:

54731623, Dec 5, 1995

Filed:

Sep 20, 1993

Appl. No.:

8/123733

Inventors:

Kenneth W. Busch - Waco TX
M. Keith Hudson - Little Rock AR
Marianna A. Busch - Waco TX
Sidney W. Kubala - Angleton TX
David C. Tilotta - Grand Forks ND
Ravishankar Srinivasan - Houston TX
Yunke Zhand - Columbia SC

Assignee:

Baylor University - Waco TX

International Classification:

G01N 2171
G01N 2162

US Classification:

2503416

Abstract:

Apparatus and method for qualitatively and quantitatively analyzing infrared emission from excited molecules in the determination of, for example, total inorganic carbon, chloride and available chlorine in aqueous samples. Methods of exciting the gas-phase, infrared-active molecules to emit radiation include flame excitation, furnace excitation, excitation by electron impact in a gas discharge or excitation by collisions with a vibrationally excited diatomic molecule. The detector is optimized by use of dual beam system with background subtraction capabilities thereby eliminating background noise and fluctuations therein.

US Patent:

52468682, Sep 21, 1993

Filed:

Sep 29, 1989

Appl. No.:

7/415141

Inventors:

Kenneth W. Busch - Waco TX
M. Keith Hudson - Little Rock AR
Marianna A. Busch - Waco TX
Sidney W. Kubala - Hewitt TX
David C. Tilotta - Waco TX
Ravishankar Srinivasan - Waco TX

Assignee:

Research Corporation Technologies, Inc. - Tucson AZ

International Classification:

G01N 2172

US Classification:

436101

Abstract:

Apparatus and method for qualitatively and quantitatively analyzing infrared emission from excited molecules in samples of interest is disclosed. Over the wavelength interval from 1 to 5 um, two strong emission bands are observed with a PbSe detector when organic compounds are introduced into an hydrogen/air flame. The band at 4. 3 um (2326 cm. sup. -1 is due to the asymmetric stretch of carbon dioxide while the band at 2. 7 um is due to both water and carbon dioxide emission. The carbon dioxide emission at 4. 3 um is most intense at the tip of the flame, and increases with the amount of organic compound introduced into the flame. For chromatographic application, an optical filter can be used to isolate the 4. 3 um emission band. The infrared emission detection system finds application in the determination of total inorganic carbon, chloride and available chlorine in aqueous samples.