Mario G Cardozo

US Patent:

6506769, Jan 14, 2003

Filed:

Aug 2, 2001

Appl. No.:

09/921509

Inventors:

Roger John Snow - Danbury CT
Mario Cardozo - Brookfield CT
Daniel Goldberg - Redding CT
Abdelhakim Hammach - Danbury CT
Tina Morwick - New Milford CT
Neil Moss - Ridgefield CT
Usha R. Patel - Brookfield CT
Hidenori Takahashi - LaGrangeville NY
Matt Aaron Tschantz - Newtown CT
Xiao-Jun Wang - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 314745

US Classification:

514293, 514290, 514393, 514397, 546 82, 546141, 546148, 5462731

Abstract:

Disclosed are novel compounds of formula (I): wherein Ar , R , R , R , X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of the formula (I).

US Patent:

6770639, Aug 3, 2004

Filed:

Nov 12, 2002

Appl. No.:

10/292026

Inventors:

Roger John Snow - Danbury CT
Mario Cardozo - Brookfield CT
Daniel Goldberg - Redding CT
Abdelhakim Hammach - Danbury CT
Tina Morwick - New Milford CT
Neil Moss - Ridgefield CT
Usha R. Patel - Brookfield CT
Hidenori Takahashi - LaGrangeville NY
Matt Aaron Tschantz - Newtown CT
Xiao-Jun Wang - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 3133

US Classification:

514183, 514293, 514290, 514393, 514397, 546 82, 546141, 546148, 5462731

Abstract:

Disclosed are novel compounds of formula (I): wherein Ar , R , R , R , X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of the formula (I).

US Patent:

6794158, Sep 21, 2004

Filed:

Mar 28, 2002

Appl. No.:

10/109433

Inventors:

Richard Harold Ingraham - New Fairfield CT
Mario G. Cardozo - Brookfield CT
Christine Anne Grygon - Redding CT
Rachel Rebecca Kroe - Bethel CT
John Robert Proudfoot - Newtown CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C12Q 134

US Classification:

435 18, 435 4, 435968

Abstract:

This invention is directed to a fluorescence polarization assay useful in the detection and evaluation of soluble epoxide hydrolase (sEH) inhibitors. This invention also relates to novel fluorescent probes used in the fluorescence polarization assay, and methods of manufacturing such fluorescent probes. This fluorescent probe of the invention is a compound having the following formula (I): wherein X is the radical of compound that binds to the active site of soluble epoxide hydrolase, Y is a fluorescent label, and âspacerâ and R are as defined herein.

US Patent:

7199119, Apr 3, 2007

Filed:

Sep 19, 2003

Appl. No.:

10/666857

Inventors:

Simon A. Burkitt - Kirkby-in-Ashfield, GB
Mario G. Cardozo - San Francisco CA, US
Timothy D. Cushing - Pacifica CA, US
Michael R. DeGraffenreid - San Francisco CA, US
Christopher N. Farthing - Macclesfield, GB
Xiaolin Hao - Foster City CA, US
Juan C. Jaen - Burlingame CA, US
XianYun Jiao - San Mateo CA, US
David J. Kopecky - San Francisco CA, US
Marc Labelle - Burlingame CA, US
Sarah E. Lively - Congleton, GB
Dustin L. McMinn - Pacifica CA, US
Sven P. Rasmussen - Congleton, GB
Youngsook Shin - San Mateo CA, US
Marie-Louise Smith - Half Moon Bay CA, US
Andrew Smith - Macclesfield, GB

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/5377
A61K 31/4365
C07D 413/14
C07D 471/04

US Classification:

5142338, 546114, 514301, 544127

Abstract:

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

US Patent:

7550473, Jun 23, 2009

Filed:

Sep 3, 2004

Appl. No.:

10/933635

Inventors:

Mario G. Cardozo - San Francisco CA, US
Derek Cogan - Sandy Hook CT, US
Charles Lawrence Cywin - Bethel CT, US
George Dahmann - Attenweiler, DE
Darren DiSalvo - New Milford CT, US
John David Ginn - New Milford CT, US
Denice M. Spero - West Redding CT, US
Erick Richard Roush Young - Danbury CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT
Boehringer Ingelheim Pharma GmbH & Co. KG - Ingelheim

International Classification:

C07D 239/42
A61K 31/505

US Classification:

514275, 544323

Abstract:

Disclosed are novel compounds of formula (I):.

US Patent:

7635695, Dec 22, 2009

Filed:

Feb 21, 2007

Appl. No.:

11/709895

Inventors:

Simon A. Burkitt - Kirkby-in-Ashfield, GB
Mario G. Cardozo - San Francisco CA, US
Timothy D. Cushing - Pacifica CA, US
Michael R. DeGraffenreid - San Francisco CA, US
Christopher N. Farthing - Macclesfield, GB
Xiaolin Hao - Foster City CA, US
Juan C. Jaen - Burlingame CA, US
Xian Yun Jiao - San Mateo CA, US
David J. Kopecky - San Francisco CA, US
Marc Labelle - Burlingame CA, US
Sarah E. Lively - Congleton, GB
Dustin L. McMinn - Pacifica CA, US
Sven P. Rasmussen - Congleton, GB
Youngsook Shin - San Mateo CA, US
Marie-Louise Smith - Half Moon Bay CA, US
Andrew Smith - Macclesfield, GB

Assignee:

Amgen Inc. - South San Francisco CA

International Classification:

A61K 31/5377
A61K 31/4365
C07D 413/14
C07D 495/04

US Classification:

5142338, 514301, 544127, 546114

Abstract:

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

US Patent:

7683059, Mar 23, 2010

Filed:

Sep 5, 2006

Appl. No.:

10/587846

Inventors:

Mario G. Cardozo - San Francisco CA, US
Jay P. Powers - Pacifica CA, US
Hiroyuki Goto - Takatsuki, JP
Kazuhito Harada - Osaka, JP
Katsuaki Imamura - Tokyo, JP
Makoto Kakutani - Takatsuki, JP
Isamu Matsuda - Tokyo, JP
Yasuhiro Ohe - Tokyo, JP
Shinji Yata - Tokyo, JP

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/4196
A61K 31/5377
C07D 413/12
C07D 249/08

US Classification:

5142362, 544106, 544111, 544132, 5482622, 5482672, 5142312, 5142358, 514383

Abstract:

The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.

US Patent:

7763624, Jul 27, 2010

Filed:

Aug 18, 2006

Appl. No.:

11/506381

Inventors:

John L. Buchanan - Newton MA, US
William H. Buckner - Kittery ME, US
Mario G. Cardozo - San Francisco CA, US
Erin F. DiMauro - Cambridge MA, US
Jiasheng Fu - Foster City CA, US
Xiaolin Hao - Foster City CA, US
Xian Yun Jiao - San Mateo CA, US
Frank Kayser - San Francisco CA, US
David J. Kopecky - San Francisco CA, US
Craig E. Masse - Cambridge MA, US
Susan A. Tomlinson - Cambridge MA, US
Ryan White - Somerville MA, US
Xiaotian Zhu - Newton MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 487/04
A61K 31/519
A61K 31/496
A61P 35/00
C07D 231/56
A61K 31/416

US Classification:

5142621, 544262, 544 61, 544118, 5142285, 5142345, 51425216, 514407, 5483621

Abstract:

The present invention relates to compounds of Formula I.