Mark J Cartwright

US Patent:

6667038, Dec 23, 2003

Filed:

Apr 20, 2000

Appl. No.:

09/553863

Inventors:

Sam T. Donta - Boston MA
Mark J. Cartwright - West Newton MA

Assignee:

Boston Medical Center Corp. - Boston MA

International Classification:

A61K 3902

US Classification:

4241901, 424 92, 4241841, 4242341, 4242361, 4242621, 530300, 530350, 536 231, 536 237

Abstract:

The present invention provides compositions and methods related to toxin and antitoxin preparations. In particular, the present invention provides methods and compositions for the diagnosis of Lyme disease, as well as for use in treating subjects infected with through passive immunization, and vaccine development.

US Patent:

20220281955, Sep 8, 2022

Filed:

Dec 16, 2021

Appl. No.:

17/552662

Inventors:

- Cambridge MA, US
Brendon Dusel - West Roxbury MA, US
Michael SUPER - Lexington MA, US
Mark CARTWRIGHT - West Newton MA, US
Donald E. INGBER - Boston MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

C07K 14/78
G01N 33/569
C07K 14/00
C07K 14/47
C07K 19/00

Abstract:

Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e g, enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.

US Patent:

20210277079, Sep 9, 2021

Filed:

May 12, 2021

Appl. No.:

17/318343

Inventors:

- Cambridge MA, US
Donald E. INGBER - Boston MA, US
Mark J. CARTWRIGHT - West Newton MA, US
Michael SUPER - Lexington MA, US
Martin ROTTMAN - St. Cloud, FR
Evangelia MURRAY - Worcester MA, US
Brendon DUSEL - West Roxbury MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

C07K 14/47
G01N 33/68
G01N 33/569
A61K 47/42

Abstract:

Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

US Patent:

20210155677, May 27, 2021

Filed:

Nov 10, 2020

Appl. No.:

17/093781

Inventors:

- Cambridge MA, US
Michael SUPER - Lexington MA, US
Jeffrey Charles WAY - Cambridge MA, US
Mark J. CARTWRIGHT - West Newton MA, US
Julia B. BERTHET - Brookline MA, US
Dinah R. SUPER - Lexington MA, US
Martin ROTTMAN - St. Cloud, FR
Alexander L. WATTERS - Melrose MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

C07K 16/12
A61K 47/68
G01N 33/543
G01N 33/569
C07K 14/42

Abstract:

Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

US Patent:

20210054073, Feb 25, 2021

Filed:

Aug 4, 2020

Appl. No.:

16/984365

Inventors:

- Darmstadt, DE
Christel Iffland - Cambridge MA, US
Olivier Leger - Saint-Sixt, FR
Qi An - Nashua NH, US
Mark Cartwright - West Newton MA, US
Sean D. McKenna - Duxbury MA, US

International Classification:

C07K 16/28
A61K 45/06
A61K 31/555
A61K 39/395
A61K 31/675
A61K 31/7068
A61K 39/00
A61K 31/282
A61K 31/513
A61K 31/519

Abstract:

The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.

US Patent:

20200283506, Sep 10, 2020

Filed:

May 20, 2020

Appl. No.:

16/879015

Inventors:

- Cambridge MA, US
Brendon Dusel - West Roxbury MA, US
Michael SUPER - Lexington MA, US
Mark CARTWRIGHT - West Newton MA, US
Donald E. INGBER - Boston MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

C07K 14/78
G01N 33/569
C07K 14/00
C07K 14/47
C07K 19/00

Abstract:

Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.

US Patent:

20200239552, Jul 30, 2020

Filed:

Nov 14, 2019

Appl. No.:

16/683630

Inventors:

- Cambridge MA, US
Michael SUPER - Lexington MA, US
Jeffrey Charles WAY - Cambridge MA, US
Mark J. CARTWRIGHT - West Newton MA, US
Julia B. BERTHET - Brookline MA, US
Dinah R. SUPER - Lexington MA, US
Martin ROTTMAN - St. Cloud, FR
Alexander L. WATTERS - Melrose MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

C07K 16/12
A61K 47/68
G01N 33/543
G01N 33/569
C07K 14/42

Abstract:

Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

US Patent:

20200103402, Apr 2, 2020

Filed:

Dec 13, 2019

Appl. No.:

16/713440

Inventors:

- Cambridge MA, US
Mark J. CARTWRIGHT - West Newton MA, US
Martin M. ROTTMAN - La Celle St Cloud, FR
Julie A. TOMOLONIS - Brighton MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

G01N 33/569
G01N 33/543
G01N 33/53

Abstract:

Methods, compositions, kits and systems for detecting and/or capturing a target entity in a sample. In particular, the methods, compositions and kits described herein can be used for pre-treatment of target-binding agents with a blocking agent to reduce non-target binding in a complex matrix (e.g., blood). Methods and compositions for detecting and/or capturing a microbe in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces are also disclosed.