James E. Kipp - Wauconda IL Mark J. Doty - Grayslake IL Christine L. Rebbeck - Algonquin IL Jan Y. Eilert - Wauconda IL
Assignee:
Baxter International - Deerfield IL
International Classification:
A61K 31343
US Classification:
514469, 514557
Abstract:
The present invention provides an amiodarone parenteral solution suitable for intravenous administration without the necessity of dilution. The parenteral solution has an amiodarone concentration from 0. 2 to 10 mg/ml and a buffer solution selected from the group consisting of lactate buffer, methanesulfonate buffer, or combinations thereof, the solution having a pH within the range from approximately 2. 5-4. 5.
Microprecipitation Method For Preparing Submicron Suspensions
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.
Preparation Of Submicron Sized Nanoparticles Via Dispersion Lyophilization
Sean Brynjelsen - Lake in the Hills IL Mark Doty - Grayslake IL James E. Kipp - Wauconda IL Nailesh Jayswal - Bensonville IL Krishnaswamy Narayanan - Waukesha WI
Assignee:
Baxter International Inc. - Deerfield IL
International Classification:
A61F 1300
US Classification:
424450, 424422, 424489
Abstract:
The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.
Microprecipitation Method For Preparing Submicron Suspensions
James E. Kipp - Wauconda IL, US Joseph Chung Tak Wong - Gurnee IL, US Mark J. Doty - Grayslake IL, US Christine L. Rebbeck - Algonquin IL, US
Assignee:
Baxter International Inc. - Deerfield IL
International Classification:
A61K009/14 A61K009/10 B01J013/00
US Classification:
424489, 424400, 424450, 264 4, 264 41, 264 5
Abstract:
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.
Method For Preparing Submicron Particle Suspensions
James E. Kipp - Wauconda IL, US Joseph Chung Tak Wong - Gurnee IL, US Mark J. Doty - Grayslake IL, US Jane Werling - Arlington Heights IL, US Christine L. Rebbeck - Algonquin IL, US Sean Brynjelsen - Lake in the Hills IL, US
Assignee:
Baxter International Inc. - Deerfield IL
International Classification:
A61K009/14 A61K009/10 B01J013/00
US Classification:
424489, 424400, 424450, 264 4, 264 41, 264 5
Abstract:
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.
Microprecipitation Method For Preparing Submicron Suspensions
James E. Kipp - Wauconda IL, US Joseph Chung Tak Wong - Gurnee IL, US Mark J. Doty - Grayslake IL, US Christine L. Rebbeck - Algonquin IL, US Sean Brynjelsen - Lake in the Hills IL, US
Assignee:
Baxter International Inc. - Deerfield IL
International Classification:
A61K009/14 A61K009/10 B01J013/00
US Classification:
424489, 424400, 424450, 264 4, 264 41, 264 5
Abstract:
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of less than about 2 μm.
Method For Preparing Submicron Suspensions With Polymorph Control
Jane Werling - Arlington Heights IL, US James E. Kipp - Wauconda IL, US Rajaram Sriram - Glenview IL, US Mark J. Doty - Grayslake IL, US
Assignee:
Baxter International Inc. - Deerfiled IL
International Classification:
A61K009/14 A61K009/10 B01J013/00
US Classification:
424489, 424400, 424450, 264 4, 264 41, 264 5
Abstract:
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.
Microprecipitation Method For Preparing Submicron Suspensions
James E. Kipp - Wauconda IL, US Joseph Chung Tak Wong - Gurnee IL, US Mark J. Doty - Grayslake IL, US Christine L. Rebbeck - Algonquin IL, US
Assignee:
Baxter International Inc. - Deerfield IL
International Classification:
A61K 9/14 A61K 9/10 B01J 13/00
US Classification:
424489, 424400, 424450, 264 4, 264 41, 264 5
Abstract:
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.
Isbn (Books And Publications)
Tell Me Who I Am: James Agee's Search for Selfhood
Each year, 10 prizes are given to a combination of authors, poets and playwrights. Past winners also have included Tony Kushner, Jonathan Franzen, David Foster Wallace, Mark Doty and Michael Cunningham.
Date: Oct 23, 2012
Category: Entertainment
Source: Google
Youtube
Poet Mark Doty Reads 'A Display of Mackerel'
Mark Doty reads his poem, "A Display of Mackerel." For more arts cover...
Duration:
2m 22s
Sharon Olds and Mark Doty in Conversation
Iconic poets Sharon Olds and Mark Doty read from their influential col...
Duration:
1h 13m 20s
The author interview with Mark Doty
Poet and memoirist Mark Doty, the Campus Festival's international gues...
Duration:
45m 51s
Mark Doty on memory, mackerel and verse
In this edition of HoCoPoLitSo's "The Writing Life," poet Sue Ellen Th...
Duration:
27m 48s
Mark Doty and Marie Howe
Harold Clurman Poetry Reading Series presents Mark Doty and Marie Howe...
Duration:
1h 13m 46s
Readings by Mark Doty
The Favorite Poem Project, in cooperation with Boston University's Sch...