Mark H Friedman

Address:

18400 Oxfordshire Ter, Olney, MD 20832

Phone:

3017747644

VIN:

YV1902FHXB2003344

Make:

VOLVO

Model:

S60

Year:

2011

Address:

18400 Oxfordshire Ter, Olney, MD 20832

VIN:

19UUA66287A033487

Make:

ACURA

Model:

TL

Year:

2007

Address:

7107 NW 106 Ave, Tamarac, FL 33321

Phone:

9543415067

VIN:

KMHDU46D07U078039

Make:

HYUN

Model:

ELAN

Year:

2007

US Patent:

20070103185, May 10, 2007

Filed:

Nov 3, 2005

Appl. No.:

11/266447

Inventors:

Mark Friedman - Eldersburg MD, US

Assignee:

Honeywell International Inc. - Morristown NJ

International Classification:

H03K 19/007

US Classification:

326014000

Abstract:

A method of operation and an apparatus for radiation hardening a combinational logic circuit are presented. A section of logic that is to be radiation hardened is identified. An entire logic circuit or a portion of the logic circuit may be radiation hardened. Once the section of logic is identified, a Field Effect Transistor (FET) is duplicated so as to create a voter FET. The voter FET is coupled with an original node (or signal) and a duplicated node (or signal). If a radiation event strikes either the original node or the duplicated node, the voter FET will prevent an upset from propagating to down stream logic by preventing a conduction path through the voter FET. Additionally, all of the circuitry that was duplicated in order to create the duplicated node may also undergo a radiation event without causing an upset to propagate to downstream logic.

US Patent:

20080137488, Jun 12, 2008

Filed:

Dec 6, 2006

Appl. No.:

11/567529

Inventors:

Mark R. Friedman - Syosset NY, US

Assignee:

Seal Systems - Syosset NY

International Classification:

H04B 1/18

US Classification:

369 6, 369 5

Abstract:

An audio system that allows audio to be stored and/or moved between components of the audio system by means of digital plug-in cards.

US Patent:

48717762, Oct 3, 1989

Filed:

Oct 22, 1987

Appl. No.:

7/112260

Inventors:

Michael J. DiNovi - Philadelphia PA
Robert J. Rafka - Groton Long Point CT
Mark I. Friedman - Merion PA
Michael G. Tordoff - Philadelphia PA

Assignee:

Monell Chemical Senses Center - Philadelphia PA

International Classification:

A61K 31045

US Classification:

514738

Abstract:

A novel fructose analog is disclosed which has been found to modify the food intake of mammals. If administered during the diurnal fasting period, the mammals increase their food intakes. If administered during the diurnal feeding period, food intake is decreased. The compound is 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol, preferably 2,5-anhydro-1,6-dichloro-dideoxy-D-mannitol ("Charmitol").

US Patent:

48086266, Feb 28, 1989

Filed:

Sep 23, 1986

Appl. No.:

6/910698

Inventors:

Mark I. Friedman - Merion PA
Michael G. Tordoff - Philadelphia PA
Michael J. DiNovi - Philadelphia PA
Robert J. Rafka - Ardmore PA

Assignee:

Monell Chemical Senses Center - Philadelphia PA

International Classification:

A61K 31045

US Classification:

514738

Abstract:

A novel method for altering the food intake of a mammal is disclosed wherein 2,5-anhydro-D-mannitol (2,5-AM) is administered to that mammal in an amount sufficient to alter its food intake. Preferably, normal feeding and fasting periods, and most preferably diurnal feeding and fasting periods, are identified. The mammal receives an intragastric, or intraperitoneal, or intravenous administration within two hours in advance of the onset of the feeding period to decrease food intake, or within two hours of the onset of the fasting period to increase intake. The subject mannitol is preferably administered in amounts of 50-800 mg/kg, although neither the lower limit of sufficiently nor the upper limit of activity have yet to be identified.

US Patent:

49545310, Sep 4, 1990

Filed:

Aug 15, 1988

Appl. No.:

7/231941

Inventors:

Mark I. Friedman - Merion PA
Michael G. Tordoff - Philadelphia PA
Michael J. DiNovi - Philadelphia PA
Robert J. Rafka - Ardmore PA

Assignee:

Monell Chemical Senses Center - Philadelphia PA

International Classification:

A61K 31045

US Classification:

514738

Abstract:

A novel method for altering the food intake of a mammal is diclosed wherein 2,5-anhydro-D-mannito (2,5-AM) is administered to that mammal in an amount sufficient to alter its food intake. Preferably, normal feeding and fasting periods, and most preferably diurnal feeding and fasting periods, are identified. The mammal receives an intragastric, or intraperitoneal, or intravenous administration within two hours in advance of the onset of the feeding period to decrease food intake, or within two hours of the onset of the fasting period to increase intake. The subject mannitol is preferably administered in amounts of 50-800 mg/kg, although neither the low limit of sufficiency nor the upper limit of activity have yet to be identified.

US Patent:

20200038491, Feb 6, 2020

Filed:

Sep 28, 2017

Appl. No.:

16/337495

Inventors:

- Boston MA, US
Zachary GOODMAN - Falls Church VA, US
Barbara BURTON - Chicago IL, US
Andrew RANKIN - Branford CT, US
Mark FRIEDMAN - Newton MA, US
Paresh SONI - Mystic CT, US

International Classification:

A61K 38/46
A61K 9/00
A61P 1/16

Abstract:

The present invention provides methods of reducing liver fibrosis in a human patient with a lysosomal acid lipase (LAL) deficiency comprising administering sebelipase alfa to the patient, wherein the patient has been determined to have at least a one point reduction (e.g., a ≥1 point reduction or a ≥2 point reduction) in Ishak fibrosis stage after administration compared to a baseline Ishak fibrosis stage obtained from the patient prior to administration. Also provided are methods of treating a human patient with a lysosomal acid lipase (LAL) deficiency comprising administering sebelipase alfa to the patient, wherein the patient has been determined to have at least a one point reduction (e.g., a ≥1 point reduction or a ≥2 point reduction) in Ishak fibrosis stage after administration compared to a baseline Ishak fibrosis stage obtained from the patient prior to administration.