Mark J Hansen

US Patent:

6727058, Apr 27, 2004

Filed:

Mar 12, 2001

Appl. No.:

09/803863

Inventors:

Frederic Bushman - Encinitas CA
Mark Hansen - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12Q 170

US Classification:

435 5, 435 6, 435 691, 435239, 435183

Abstract:

The present invention provides packaging cell lines and recombinant lentiviral or retroviral particles produced therefrom, particularly pseudotyped retroviral particles. The packaging cell lines of the invention are produced by inducibly expressing an envelope protein by methods described herein. Also described is a screening assay for compounds that affect integration of viral nucleic acid into target (e. g. , host) nucleic acid. Such compounds are identified based on their effect on viral integrase.

US Patent:

6792355, Sep 14, 2004

Filed:

Dec 21, 2001

Appl. No.:

10/032395

Inventors:

Mark R. Hansen - San Diego CA
Richard Kho - San Diego CA
Hugo O. Villar - La Jolla CA

Assignee:

Triad Therapeutics, Inc. - San Diego CA

International Classification:

G06F 1700

US Classification:

702 19, 702 20

Abstract:

The invention provides a method for separating two or more subsets of polypeptides within a set of polypeptides. The method includes the steps of: (a) determining a sequence comparison signature for each amino acid sequence in a set of amino acid sequences, wherein the sequence comparison signature includes pairwise comparison scores for the amino acid sequence compared to each of the other amino acid sequences in the set; (b) constructing a distance arrangement including the sequence comparison signatures related according to the distance between each of the sequence comparison signatures; and (c) identifying a first and second cluster of sequence comparison signatures in the distance arrangement, wherein the first cluster includes sequence comparison signatures for polypeptides having a similar protein fold or biological function, the protein fold or function being different compared to a protein fold or function of polypeptides having sequence comparison signatures in the second cluster.

US Patent:

7013803, Mar 21, 2006

Filed:

Feb 6, 2002

Appl. No.:

10/071778

Inventors:

Mark R. Hansen - Wauwatosa WI, US
Glen W. Rantala - Menomonee Falls WI, US
Bradly Moersfelder - Waukesha WI, US

Assignee:

Quad/Tech, Inc. - Sussex WI

International Classification:

B41F 5/16
B41M 1/14
G03B 27/32

US Classification:

101181, 101148, 101211, 101355, 101426, 355 32, 355 35

Abstract:

A color registration control system for a printing press including an area scanner for acquiring an image of a paper substrate and an image processing system adapted to receive the image and process the image to determine any color register error.

US Patent:

7423280, Sep 9, 2008

Filed:

Aug 9, 2004

Appl. No.:

10/914372

Inventors:

Eric Pearson - Consestogo, CA
Mark R. Hansen - Wauwatosa WI, US
Bradly S. Moersfelder - Waukesha WI, US
Patrick James Noffke - Devon Park, AU
John C. Seymour - Genesee Depot WI, US

Assignee:

Quad/Tech, Inc. - Sussex WI

International Classification:

G01N 21/86
G01N 21/84
H04N 1/04

US Classification:

25055939, 356429, 358474

Abstract:

A web inspection module is described for scanning an imprinted web in a printing press. The web inspection module includes a light source for illuminating a portion of the web, a contact image sensor having a plurality of sensing elements, and a processor for receiving and processing image data representative of the imprinted web.

US Patent:

7732796, Jun 8, 2010

Filed:

Jul 16, 2008

Appl. No.:

12/174481

Inventors:

Eric Pearson - Consestogo, CA
Mark R. Hansen - Wauwatosa WI, US
Bradly S. Moersfelder - Waukesha WI, US
Patrick James Noffke - Devon Park, AU
John C. Seymour - Genesee Depot WI, US

Assignee:

Quad/Tech, Inc. - Sussex WI

International Classification:

G01N 21/86
G01V 8/00

US Classification:

25055939, 356429, 358474

Abstract:

An inspection system for inspecting an imprinted substrate on a printing press has a light source, a contact image sensor, and a processor. The light source is configured to illuminate a portion of the substrate which has been imprinted with different colors at a plurality of printing units of the printing press. The contact image sensor has a plurality of sensing elements. Each sensing element senses light reflected by a corresponding region on the substrate to produce data representative of the corresponding region printed on the substrate. The processor is configured to receive the data representative of the imprinted substrate and to compare the data representative of the corresponding region printed on the substrate with stored reference data.

US Patent:

8039826, Oct 18, 2011

Filed:

Apr 22, 2010

Appl. No.:

12/765723

Inventors:

Eric Pearson - Consestogo, CA
Mark R. Hansen - Wauwatosa WI, US
Bradly S. Moersfelder - Waukesha WI, US
Patrick James Noffke - Devon Park, AU
John C. Seymour - Genesee Depot WI, US

Assignee:

Quad/Tech, Inc. - Sussex WI

International Classification:

G01N 21/86
G01V 8/00

US Classification:

25055939, 356429, 358474

Abstract:

A method of inspecting an imprinted substrate on a printing press comprises illuminating a portion of the substrate which has been imprinted with different colors at a plurality of printing units of the printing press. The method further comprises sensing light reflected by the substrate using a contact image sensor to produce data representative of the imprinted substrate, and comparing the data representative of the printed substrate with stored reference data.

US Patent:

8183550, May 22, 2012

Filed:

Jun 29, 2011

Appl. No.:

13/172522

Inventors:

Eric Pearson - Consestogo, CA
Mark R. Hansen - Wauwatosa WI, US
Bradly S. Moersfelder - Waukesha WI, US
Patrick James Noffke - Devon Park, AU
John C. Seymour - Genesee Depot WI, US

Assignee:

Quad/Tech, Inc. - Sussex WI

International Classification:

G01N 21/86
G01V 8/00

US Classification:

25055939, 356429, 358474

Abstract:

A method of imaging an imprinted substrate on a printing press is provided. The method comprises sensing light reflected by the substrate using a contact image sensor to produce data representative of the imprinted substrate. The substrate has been imprinted with different colors at a plurality of printing units of the printing press. Each printing unit comprises a plate cylinder. The method further comprises storing the data representative of the imprinted substrate in a memory.

US Patent:

8586956, Nov 19, 2013

Filed:

May 18, 2012

Appl. No.:

13/475746

Inventors:

Eric Pearson - Consestogo, CA
Mark R. Hansen - Wauwatosa WI, US
Bradly S. Moersfelder - Waukesha WI, US
Patrick James Noffke - Devon Park, AU
John C. Seymour - Genesse Depot WI, US

Assignee:

Quad/Tech, Inc. - Sussex WI

International Classification:

G01N 21/86
G01V 8/00

US Classification:

25055939, 356429, 358474

Abstract:

Systems and methods for imaging an imprinted substrate on a printing press is provided. One method comprises sensing light reflected by the substrate using a contact image sensor to produce data representative of the imprinted substrate. The substrate has been imprinted with different colors at a plurality of printing units of the printing press. Each printing unit comprises a plate cylinder. The data representative of the imprinted substrate is output by the contact image sensor as analog voltage signals. The method further comprises receiving the analog voltage signals from the contact image sensor at a sensor interface circuit and converting the analog voltage signals to digital signals using an analog-to-digital converter of the sensor interface circuit. The method further comprises processing the digital signals using the sensor interface circuit to produce corrected digital signals and storing data based on the corrected digital signals in a memory.