Mark A Jenkins

US Patent:

6476192, Nov 5, 2002

Filed:

Apr 15, 1996

Appl. No.:

08/624677

Inventors:

Nicola C. Lally - McLean VA 22102
Mark C. Jenkins - Bowie MD 20716
Jitender P. Dubey - Greenbelt MD 20770

International Classification:

C07K 100

US Classification:

530350, 30300, 4241841, 4242651, 4242661, 4242691, 435 71, 435 721, 435 792, 435 8, 435 35, 436538

Abstract:

Antigens for the detection of antibodies to Neospora parasites for the diagnosis of neosporosis have been identified. Recombinant antigens may be produced by expression of DNA sequences derived from Both antigens are capable of detecting antibody responses in animals experimentally inoculated with but show no evidence of cross-reactivity with serum from animals inoculated with closely related parasites such as or Sarcocystis species.

US Patent:

6521229, Feb 18, 2003

Filed:

Jun 26, 2001

Appl. No.:

09/888655

Inventors:

Mark C. Jenkins - Davidsonville MD
Ronald Fayer - Columbia MD
James Trout - Columbia MD

Assignee:

The United States of America as represented by the Secretary of Agriculture - Washington DC

International Classification:

A61K 39395

US Classification:

4241511, 4241991, 4242691, 435 722, 435342, 5303881, 5303886, 5303891

Abstract:

Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against , particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

US Patent:

6710166, Mar 23, 2004

Filed:

Jun 26, 2001

Appl. No.:

09/888501

Inventors:

Mark C. Jenkins - Davidsonville MD
Ron Fayer - Columbia MD
James Trout - Columbia MD

Assignee:

The United States of America as represented by the Secretary of Agriculture - Washington DC

International Classification:

A61K 3800

US Classification:

530300, 4241511, 4241911, 4242691, 435 722, 435342

Abstract:

Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against , particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

US Patent:

20130017220, Jan 17, 2013

Filed:

Jul 11, 2012

Appl. No.:

13/546455

Inventors:

Mark C. Jenkins - Davidsonville MD, US
Raymond H. Fetterer - College Park MD, US
Joseph T. Persyn - San Antonio TX, US

International Classification:

A61K 39/002
A61P 33/02
A61K 39/012

US Classification:

4242711, 4242691

Abstract:

Safe and effective gel-bead vaccines for treating domesticated birds for diseases caused by cyst-forming protozoa, especially for coccidiosis.

US Patent:

55914349, Jan 7, 1997

Filed:

Apr 15, 1994

Appl. No.:

8/229393

Inventors:

Mark C. Jenkins - Bowie MD
Ronald Fayer - Ellicott City MD
Michael Tilley - Manhattan KS
Steven L. Upton - Manhattan KS

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC
Kansas State University Research Foundation - Manhattan KS

International Classification:

A61K 39002
A61K 39395
C07K 1444
C07K 1620
C12N 1530
C12N 121
C12P 2102
C12P 2108

US Classification:

4241911

Abstract:

Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The Proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

US Patent:

62779737, Aug 21, 2001

Filed:

Nov 30, 1999

Appl. No.:

9/451117

Inventors:

Mark C. Jenkins - Davidsonville MD
Ron Fayer - Columbia MD
James Trout - Columbia MD

Assignee:

The United States of America as represented by the Secretary of Agriculture - Washington DC

International Classification:

C07H 2102

US Classification:

536 231

Abstract:

Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

US Patent:

51224712, Jun 16, 1992

Filed:

Feb 9, 1989

Appl. No.:

7/308219

Inventors:

Mark C. Jenkins - Bowie MD
Hyun S. Lillehoj - West Friendship MD
John B. Dame - Gainesville FL
Harry D. Danforth - Severn MD
Michael D. Ruff - Bowie MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C12N 121
C12N 1500
C12N 1570
C12P 2102
C12P 1934

US Classification:

4352523

Abstract:

Disclosed are DnA sequences which code for antigenic proteins, methods for identifying such DNA sequences, and antigens coded for by such DNA sequences. The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted with antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted with white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-mediated immune response to avian coccidiosis. The DNA sequences of the present invention comprise cloned genes or fragments thereof that code on expression for an antigenic protein that activates white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein.

US Patent:

20090208519, Aug 20, 2009

Filed:

Feb 20, 2008

Appl. No.:

12/070684

Inventors:

Wenbin Tuo - Clarksville MD, US
Mark C. Jenkins - Davidsonville MD, US
Yan Zhao - Herndon VA, US

International Classification:

A61K 39/00
A61P 31/00

US Classification:

4241861

Abstract:

p-00010000