Mark W Kelley

US Patent:

20100145200, Jun 10, 2010

Filed:

Dec 7, 2009

Appl. No.:

12/632637

Inventors:

Matthew D. Keller - Bothell WA, US
Mark C. Kelley - Nashville TN, US

Assignee:

VANDERBILT UNIVERSITY - Nashville TN

International Classification:

A61B 6/00

US Classification:

600476

Abstract:

The present invention in one aspect relates to a method for surgical margin evaluation of tissues during breast conserving therapy at a surgical site of interest. In one embodiment, the method comprises the steps of acquiring a plurality of spatially offset Raman spectra from the surgical site of interest, identifying tissue signatures from the plurality of spatially offset Raman spectra, and determining surgical margins of the surgical site from the identified tissue signatures.

US Patent:

20150164336, Jun 18, 2015

Filed:

Feb 12, 2015

Appl. No.:

14/620846

Inventors:

- NASHVILLE TN, US
Matthew D. Keller - Kirkland WA, US
Mark C. Kelley - Franklin TN, US

International Classification:

A61B 5/00

Abstract:

The invention in one aspect relates to a method for discriminating soft biological tissues. The method includes illuminating soft biological tissues at at least one first spot with light; collecting Raman scattering light scattered from the soft biological tissues at least second spot in response to illumination by the light, wherein the at least second spot is away from the at least one first spot so as to define a source-detection (S-D) offset distance therebetween; obtaining a spatially offset Raman spectrum from the collected light, wherein the spatially offset Raman spectrum is associated with a depth of the soft biological tissues at which the Raman light is scattered; identifying tissue signatures from the spatially offset Raman spectrum; and determining whether the soft biological tissues have a layered structure from the tissue signatures from the spectrum.