Mark S Maxwell

US Patent:

20030100005, May 29, 2003

Filed:

Nov 25, 2002

Appl. No.:

10/303685

Inventors:

Felix Karim - Walnut Creek CA, US
Linda Keyes - San Carlos CA, US
Gregory Plowman - San Carlos CA, US
Michael Ollmann - Redwood City CA, US
Mark Maxwell - San Francisco CA, US
Thierry Diagana - San Francisco CA, US

International Classification:

C12Q001/68
G01N033/574
A61K048/00

US Classification:

435/006000, 435/007230, 514/044000

Abstract:

Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.

US Patent:

20040142888, Jul 22, 2004

Filed:

Aug 7, 2003

Appl. No.:

10/638225

Inventors:

Veeraswamy Manne - Philadelphia PA, US
Mark Lynch - Madison CT, US
Petra Ross-MacDonald - Pennington NJ, US
Terry Stouch - West Windsor NJ, US
Naomi Laing - Stoneham MA, US
Pamela Carroll - Princeton NJ, US
Kevin Fitzgerald - Lambertville NJ, US
Louis Lombardo - Belle Mead NJ, US
Michael Costa - San Francisco CA, US
Mark Maxwell - San Francisco CA, US
Rachel Kindt - San Carlos CA, US
Mark Lackner - Brisbane CA, US
Tak Hung - Foster City CA, US
Carol O'Brian - Castro Valley CA, US
Hai Zhang - El Sobrante CA, US
Katherine Brown - San Francisco CA, US
Jae Lee - Cupertino CA, US

International Classification:

A61K048/00
G01N033/574
A61K031/5513
A61K031/47

US Classification:

514/044000, 514/221000, 514/310000, 435/007230

Abstract:

The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein. The present invention further provides a 3-dimensional structure of RabGGT, and methods of use of the structure to identify compounds that modulate RabGGT activity.

US Patent:

20060084063, Apr 20, 2006

Filed:

Jul 9, 2003

Appl. No.:

10/520836

Inventors:

Michael Costa - San Francisco CA, US
Mark Maxwell - Lansdale PA, US
Mark Lackner - Brisbane CA, US
Tak Hung - Foster City CA, US
Carol OBrien - Pacifica CA, US
Timothy Heuer - El Granada CA, US
Kim Lickteig - San Francisco CA, US

International Classification:

C12Q 1/68
G01N 33/567
G01N 33/53

US Classification:

435006000, 435007200

Abstract:

Human RAB genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of RAB are provided.

US Patent:

20080163386, Jul 3, 2008

Filed:

Jan 28, 2007

Appl. No.:

11/627977

Inventors:

Felix D. Karim - Walnut Creek CA, US
Linda Nolan Keyes - San Carlos CA, US
Gregory D. Plowman - San Carlos CA, US
Michael Martin Ollmann - Redwood City CA, US
Mark E. Maxwell - San Francisco CA, US
Thierry Tidiane Diagana - San Francisco CA, US

Assignee:

EXELIXIS, INC. - South San Francisco CA

International Classification:

G01N 33/483
G01N 33/50
C12N 5/06
C12Q 1/02

US Classification:

800 3, 436 86, 436 96, 435 29, 435377

Abstract:

Human CRB genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CRB are provided.

US Patent:

20120330855, Dec 27, 2012

Filed:

Jun 24, 2011

Appl. No.:

13/168874

Inventors:

Mark W. Maxwell - San Carlos CA, US
Vicki C. Mar - San Carlos CA, US
Steven M. Fogel - San Carlos CA, US
Terry D. Howell - Forest Grove OR, US
Chris R. Kosmakos - Martinez CA, US
Douglass Matthews - Prague, CZ

Assignee:

MONSTER WORLDWIDE, INC. - New York NY

International Classification:

G06Q 10/00

US Classification:

705320

Abstract:

Systems and methods are provided for translating military occupations and MOS codes into civilian skills and civilian occupations. The military duties associated with a MOS code are mapped to equivalent or relevant civilian skills and civilian occupations. A user's selection of MOS codes, subspecialties, trainings, licenses or work experiences are mapped to one or more civilian skills, which in turn can be mapped to one or more civilian occupations and used to generate a set of matching civilian jobs.

US Patent:

60150297, Jan 18, 2000

Filed:

Aug 4, 1998

Appl. No.:

9/130033

Inventors:

Mark A. Maxwell - Auburn WA

International Classification:

F16N 3100

US Classification:

184106

Abstract:

An apparatus for installation of a transmission fluid pan drain provides upper and lower deformation plates attachable to opposed sides of the transmission fluid pan by a threaded stud. The upper and lower deformation plates are sized and shaped so that when torque is applied to nuts carried on the threaded stud the plates are forced together, thereby deforming the transmission fluid pan, causing a depression or dimple in the fluid pan. After removing the deformation plates and stud, a hollow bolt is attachable in a fluid-tight manner to the transmission fluid pan in a manner wherein an upper end is carried above the pan and a lower threaded end is carried below the pan. An end cap is attachable to the threaded lower end of the hollow bolt, allowing transmission fluid to be drained by removing the end cap.