Robert C. Moschel - Frederick MD M. Eileen Dolan - Oak Park IL Anthony E. Pegg - Hershey PA Mark G. McDougall - Cleveland OH Mi-Young Chae - Frederick MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC The Penn State Research Foundation - University Park PA Arch Development Corporation - Chicago IL
Novel O. sup. 6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O. sup. 6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful for treating tumors and when used with anti-neoplastic alkylating agents enhance the chemotherapeutic treatment of tumor cells in a host.