Caris Life Sciences
Vice President - Research, Development and Clinical Science
Onconex Consulting Jan 2015 - Aug 2015
Owner
Caris Life Sciences Jan 2015 - Aug 2015
Vice President, Research and Development
Cielo Therapeutics Feb 2015 - Jul 2015
Interim Chief Scientific Officer
Genecentric Diagnostics May 2013 - Aug 2014
Chief Scientific Officer
Education:
University of Virginia 1988 - 1995
Doctorates, Doctor of Philosophy, Microbiology
Virginia Tech 1984 - 1988
Bachelors, Bachelor of Science, Biology
Sparta High School
Skills:
Oncology Drug Discovery Cancer Drug Development Biotechnology Clinical Development Translational Medicine Immunology Pharmaceutical Industry Clinical Research Biomarkers Translational Research Molecular Biology Pharmacology Biomarker Discovery Biochemistry Clinical Trials Cell Biology Assay Development Biopharmaceuticals Protein Chemistry Cro Cell Genomics In Vitro Inflammation
Jan 2015 to 2000 OwnerGeneCentric Diagnostics Durham, NC May 2013 to Jul 2014 Chief Scientific OfficerOncology Translational and Clinical Science Farmingdale, NY 2012 to 2013 Vice PresidentOncology Translational and Clinical Science Farmingdale, NY 2011 to 2012 Vice PresidentOncology Translational and Clinical Science
2009 to 2011 Vice PresidentOncology Translational and Clinical Science
2007 to 2009 Senior DirectorTranslational Research, Array BioPharma, Inc Boulder, CO 2005 to 2007 Assistant. DirectorDepartment of Cancer Biology, Bayer HealthCare Pharmaceuticals West Haven, CT 2004 to 2005 Section HeadBayer
2002 to 2004 Segment Representative and Principal Research Scientist IBayer
1997 to 2002 Research Scientist, Senior Research Scientist I and II
Education:
Yale University School of Medicine 1995 to 1997 Doctoral in Research DepartmentUniversity of Virginia Charlottesville, VA 1988 to 1995 Ph.D. in Cancer CenterVirginia Polytechnic Institute and State University Blacksburg, VA 1984 to 1988 B.S. in Biology
Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.
Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
- Irving TX, US Tassilo Hornung - Phoenix AZ, US Heather O'Neill - Mesa AZ, US Mark Miglarese - Phoenix AZ, US David Spetzler - Paradise Valley AZ, US
International Classification:
C12N 15/115 C12N 15/10 C12Q 1/6883 C12Q 1/6886
Abstract:
Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
- Irving TX, US Xianghua Liu - Chandler AZ, US Mark Miglarese - Phoenix AZ, US David Spetzler - Paradise Valley AZ, US
Assignee:
Caris Science, Inc. - Irving TX
International Classification:
A61K 31/7125 C12Q 1/6811 C12Q 1/6886
Abstract:
Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include circulating biomarkers such as micro vesicles, including those derived from various diseases.
- Irving TX, US Mark Miglarese - Phoenix AZ, US David Spetzler - Paradise Valley AZ, US
International Classification:
C12N 15/115 A61K 31/711 A61K 47/68 G01N 33/53
Abstract:
Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.
- Irving TX, US Adam STARK - Surprise AZ, US Nianqing XIAO - Rockville MD, US Zhenyu ZHONG - Peoria AZ, US Mark MIGLARESE - Phoenix AZ, US David SPETZLER - Paradise Valley AZ, US
Assignee:
Caris Science, Inc. - Irving TX
International Classification:
C12N 15/115 C12Q 1/6886 C40B 20/08 G01N 33/50
Abstract:
Methods and compositions are provided for oligonucleotide probes and oligonucleotide probe libraries that recognize targets of interest. The targets include circulating biomarkers such as microvesicles, including those derived from various diseases.
- Irving TX, US Heather O'Neill - Mesa AZ, US Mark Miglarese - Phoenix AZ, US David Spetzler - Paradise Valley AZ, US
International Classification:
C12N 15/115 C12Q 1/70 A61K 31/7088
Abstract:
Methods and compositions are provided for oligonucleotides and libraries of oligonucleotides that bind targets of interest. The targets include cellular biomarkers of viral infection. The viral infection may be that of human immunodeficiency virus-1.
Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.