Mark David Moody

US Patent:

20100234277, Sep 16, 2010

Filed:

Mar 27, 2007

Appl. No.:

12/295017

Inventors:

Mark Moody - Concord MA, US
Edward J. Stewart - Winchester MA, US
Brian L. Hamilton - Newton MA, US
James Murray - Duxbury MA, US

International Classification:

A61K 38/14
A61K 38/16
A61P 29/00
A61P 19/02

US Classification:

514 8, 514 12

Abstract:

The present invention relates to methods for treating an anti-inflammatory arthritic disease by coadministering therapeutically effective amounts of an alpha-fetoprotein (or a biologically active fragment thereof) and a disease modifying anti-rheumatic drug (DMARD) to a patient in need thereof. Also disclosed are compositions and kits that include therapeutically effective amounts of an alpha-fetoprotein (or a biologically active fragment thereof) and a DMARD.

US Patent:

20130203616, Aug 8, 2013

Filed:

Apr 26, 2011

Appl. No.:

13/643634

Inventors:

Sam Shenghua Song - Walpole MA, US
Arthur J. Kudla - Andover MA, US
Mark David Moody - Concord MA, US

Assignee:

MERRIMACK PHARMACEUTICALS - Cambridge MA

International Classification:

G01N 33/68

US Classification:

506 9, 435 794, 435 793, 435 792

Abstract:

Methods and kits for detecting antibodies (e.g., anti-drug antibodies) specific for abundant body fluid components are provided. Such methods and kits permit the detection of, for example, human serum albumin in human body fluids, such as blood, plasma and serum.

US Patent:

20230065872, Mar 2, 2023

Filed:

Jun 3, 2022

Appl. No.:

17/831645

Inventors:

- Woburn MA, US
Philip Wuthrich - Lowell MA, US
Robert P. Mahoney - Newbury MA, US
Mark Moody - Concord MA, US
Daniel G. Greene - Reading MA, US
Neil L. Schauer - Milford MA, US

International Classification:

A61K 47/22
A61K 39/395
A61K 47/18
A61K 9/00
A61K 47/12
A61K 47/60
A61K 47/24
A61K 47/20
C07K 16/00
A61K 47/42
A61K 38/38
A61K 38/47
C12N 9/36
C12N 9/96
A61K 38/19
A61K 38/17
A61K 47/02
A61K 38/18
C07K 16/22
C07K 16/32

Abstract:

Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, and low molecular weight aliphatic polyacids, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.

US Patent:

20230028812, Jan 26, 2023

Filed:

Sep 16, 2022

Appl. No.:

17/933071

Inventors:

- Woburn MA, US
Philip WUTHRICH - Watertown MA, US
Rosa Casado PORTILLA - Middleton MA, US
Robert P. MAHONEY - Newbury MA, US
Mark MOODY - Concord MA, US

International Classification:

A61K 47/22
A61K 47/60
A61K 9/00
A61K 38/38
A61K 38/47
C12N 9/36
C12N 9/96
C07K 16/00
A61K 39/395
A61K 47/12
A61K 47/18
A61K 47/20
A61K 47/24
A61K 47/42

Abstract:

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.

US Patent:

20210379185, Dec 9, 2021

Filed:

May 27, 2021

Appl. No.:

17/332521

Inventors:

- Woburn MA, US
Philip Wuthrich - Watertown MA, US
Robert P. Mahoney - Newbury MA, US
Mark Moody - Concord MA, US
Daniel G, Greene - Reading MA, US
Neil Schauer - Milford MA, US
Subhashchandra Naik - Watertown MA, US

International Classification:

A61K 47/22
A61K 9/00
A61K 38/38
A61K 38/47
C12N 9/36
C12N 9/96
C07K 16/00
A61K 39/395
A61K 47/12
A61K 47/18
A61K 47/20
A61K 47/24
A61K 47/42
A61K 47/60

Abstract:

Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, aromatics and anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, low molecular weight aliphatic polyacids, diones and sulfones, zwitterionic excipients, and crowding agents with hydrogen bonding elements, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.

US Patent:

20210162046, Jun 3, 2021

Filed:

Feb 12, 2021

Appl. No.:

17/175162

Inventors:

- Woburn MA, US
Philip Wuthrich - Watertown MA, US
Rosa Casado Portilla - Middleton MA, US
Robert P. Mahoney - Newbury MA, US
Mark Moody - Concord MA, US
Daniel G. Greene - Reading MA, US

International Classification:

A61K 39/395
C07K 16/24
C07K 16/32
C07K 16/22
A61K 47/22
A61K 47/12
A61K 47/02
A61K 38/17
A61K 47/20
A61K 47/18
A61K 47/42
A61K 47/60
C12N 9/36
C12N 9/96
A61K 38/19
A61K 38/18

Abstract:

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.

US Patent:

20200114002, Apr 16, 2020

Filed:

Oct 21, 2019

Appl. No.:

16/659046

Inventors:

- Woburn MA, US
Philip Wuthrich - Watertown MA, US
Rosa Casado Portilla - Middleton MA, US
Robert P. Mahoney - Newbury MA, US
Mark Moody - Concord MA, US
Daniel G. Greene - Belmont MA, US

International Classification:

A61K 39/395
A61K 47/12
A61K 47/22
C07K 16/22
C07K 16/32
C07K 16/24
A61K 38/18
A61K 38/19
C12N 9/96
C12N 9/36
A61K 47/60
A61K 47/42
A61K 47/18
A61K 47/20
A61K 38/17
A61K 47/02

Abstract:

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.

US Patent:

20190262455, Aug 29, 2019

Filed:

Feb 25, 2019

Appl. No.:

16/284583

Inventors:

- Woburn MA, US
Philip Wuthrich - Watertown MA, US
Rosa Casado Portilla - Middleton MA, US
Robert P. Mahoney - Newbury MA, US
Mark Moody - Concord MA, US

International Classification:

A61K 47/22
A61K 47/60
C12N 9/96
A61K 39/395
A61K 47/12
A61K 47/18
A61K 47/20
A61K 47/24
A61K 47/42
A61K 38/47
A61K 38/38
C07K 16/00
A61K 9/00
C12N 9/36

Abstract:

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.