Mark S Perreault

US Patent:

7404873, Jul 29, 2008

Filed:

Dec 13, 2004

Appl. No.:

11/010893

Inventors:

Michael Heath - Chelmsford MA, US
Mark Perreault - Leominster MA, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

B32B 37/00
B29C 65/00

US Classification:

1563096, 156267, 1563082, 422101

Abstract:

A method is provided for attaching a membrane to a substrate by heat-bonding the membrane to the substrate. The substrate includes a top surface, a bottom surface and a receptacle therethrough. The membrane can be a porous support structure combined with a polymeric gel. The method includes the steps of inserting a mandrel into the receptacle, placing the membrane on the substrate across the receptacle, heating the membrane and substrate, and allowing the substrate to cool to provide heat-bonded interlock between the substrate and the membrane.

US Patent:

7531632, May 12, 2009

Filed:

Feb 16, 2006

Appl. No.:

11/355557

Inventors:

Mark A. Perreault - Leominster MA, US

Assignee:

GTC Biotherapeutics, Inc. - Framingham MA

International Classification:

C07K 1/00

US Classification:

530366, 530412, 530416, 530418

Abstract:

Processes and apparati are provided for separating molecules of interest from a mixture by depth filtration (DF). The DF of the invention is useful in the clarification and processing of various feedstreams for the removal of a molecule of interest. According to a preferred embodiment, a transgenic milk feedstream is stabilized and particulate matter such as fat, casein miscelles and bacteria are removed. An aseptic filtration step was also developed to remove any bacteria remaining in a clarified transgenic milk feedstream.

US Patent:

20040033168, Feb 19, 2004

Filed:

May 12, 2003

Appl. No.:

10/435856

Inventors:

Kevin Hughes - Burlington MA, US
Mark Perreault - Leominster MA, US

Assignee:

Becton, Dickinson and Company

International Classification:

G01N001/10
B01L003/02

US Classification:

422/100000, 436/180000

Abstract:

A self-aliquoting dispensing unit for use with a multi-receptacle storage unit is provided including a lower plate having a plurality of access ports therethrough, wherein at least one of the access ports is in fluid communication with a microtube, an upper plate releasably attached to the lower plate, the upper plate including a sample port for supplying a sample to the dispensing unit, and a sealing member for forming a reversible fluid tight connection between the storage unit and the upper plate. An assembly for dispensing a sample into a multi-receptacle storage unit and a method for dispensing a sample into a multi-receptacle storage unit are also provided.

US Patent:

20050197496, Sep 8, 2005

Filed:

Feb 4, 2005

Appl. No.:

11/051216

Inventors:

Mark Perreault - Leominster MA, US

International Classification:

A61K038/17
C07K001/34

US Classification:

530412000

Abstract:

Processes and apparati are provided for separating molecules of interest from a mixture containing them which comprises subjecting the mixture to an improved method of high performance tangential flow filtration (HPTFF). The HPTFF of the invention was used to clarify, and process various feedstreams for the removal of a molecule of interest based on both the size and charge of the molecule of interest. According to a preferred embodiment, a transgenic milk feedstream is stabilized and particulate matter such as fat, casein miscelles and bacteria are removed. The method of HPTFF used in the current invention utilizes optimized process parameters that include temperature, trans-membrane pressure, molecular charge, molecular size, cross-flow velocity, and milk concentration. Cleaning and storage procedures were also developed to ensure long membrane life. An aseptic filtration step was also developed to remove any bacteria remaining in a clarified transgenic milk feedstream.

US Patent:

20100056757, Mar 4, 2010

Filed:

Apr 3, 2009

Appl. No.:

12/417832

Inventors:

Mark A. Perreault - Leominster MA, US

Assignee:

GTC Biotherapeutics, Inc, - Framingham MA

International Classification:

C07K 16/00
C07K 1/34
C07K 14/00

US Classification:

5303871, 530412, 530395

Abstract:

Processes and apparati are provided for separating molecules of interest from a mixture by depth filtration (DF). The DF of the invention is useful in the clarification and processing of various feedstreams for the removal of a molecule of interest. According to a preferred embodiment, a transgenic milk feedstream is stabilized and particulate matter such as fat, casein miscelles and bacteria are removed. An aseptic filtration step was also developed to remove any bacteria remaining in a clarified transgenic milk feedstream.

US Patent:

20210039045, Feb 11, 2021

Filed:

Jul 28, 2020

Appl. No.:

16/940764

Inventors:

- WALTHAM MA, US
Mark A. Perreault - Leominster MA, US

Assignee:

REPLIGEN CORPORATION - WALTHAM MA

International Classification:

B01D 61/14
B01D 61/18
B01D 61/22
B01D 63/16

Abstract:

The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.