Mark A Plummer

US Patent:

6875765, Apr 5, 2005

Filed:

May 10, 2002

Appl. No.:

10/143675

Inventors:

James Knobelsdorf - Knoblesville IN, US
Sheryl Hays - Ann Arbor MI, US
Charles J. Stankovic - Saline MI, US
Kimberly S. Para - Ann Arbor MI, US
Michael K. Connolly - Ypsilanti MI, US
Paul Galatsis - Ann Arbor MI, US
William Harter - Chelsea MI, US
Aurash B. Shahripour - Ann Arbor MI, US
Mark Stephen Plummer - Dexter MI, US
Beth Lunney - San Diego CA, US
Bernd Janssen - Marlborough MA, US
Jay Bradford Fell - Longmont CO, US

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D295/14
C07D407/12
C07D487/04
A61K031/495
A61P019/02

US Classification:

5142382, 51425212, 514303, 514311, 514312, 514307, 514331, 514365, 514368, 514394, 514400, 514405, 514562, 544159, 544399, 546118, 546149, 546157, 546172, 546235, 548154, 548204, 5483087, 5483097, 5483385, 5483625, 562430

Abstract:

The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized structure: and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof. In addition, methods of treating stroke, inflammatory diseases, septic shock, repurfusion injury, Alzheimer's disease, and shigellosis, using a compound of the invention or a pharmaceutical composition thereof, are described.

US Patent:

7273877, Sep 25, 2007

Filed:

Jun 24, 2004

Appl. No.:

10/876100

Inventors:

Shannon Leigh Black - Heidelberg, DE
Michael David Kaufman - Ypsilanti MI, US
Daniel Fred Ortwine - Saline MI, US
Mark Stephen Plummer - Dexter MI, US
John Quin, III - Ann Arbor MI, US
Gordon William Rewcastle - Auckland, NZ
Aurash B. Shahripour - Ann Arbor MI, US
Julie Ann Spicer - Auckland, NZ
Christopher Emil Whitehead - Ypsilanti MI, US

Assignee:

Warner-Lambert Company, LLC - Morris Plains NJ

International Classification:

A61K 31/4439
C07D 413/04
C07D 213/72

US Classification:

514340, 514349, 5462694, 546297

Abstract:

The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.

US Patent:

20040259926, Dec 23, 2004

Filed:

Jun 3, 2004

Appl. No.:

10/860348

Inventors:

Michelle Bruendl - Ann Arbor MI, US
Michael Connolly - Ypsilanti MI, US
Annise Goodman - West Bloomfield MI, US
Rocco Gogliotti - Pinckney MI, US
Helen Lee - Ann Arbor MI, US
Mark Plummer - Dexter MI, US
Karen Sexton - Chelsea MI, US
Aurash Shahripour - Ann Arbor MI, US
Greg Reichard - Ann Arbor MI, US
Melean Visnick - Ann Arbor MI, US
Michael Wilson - Ann Arbor MI, US

International Classification:

A61K031/41
C 07D 4 9/02

US Classification:

514/381000, 548/251000

Abstract:

The present invention provides benzo[b]thiophenes of Formula I: wherein R, R, R, R, R, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

US Patent:

20050004186, Jan 6, 2005

Filed:

Dec 1, 2003

Appl. No.:

10/725206

Inventors:

Stephen Barrett - Hartland MI, US
Cathlin Flamme - Lawrenceville NJ, US
Michael Kaufman - Ypsilanti MI, US
Mark Plummer - Dexter MI, US
Jessica Reed - Ann Arbor MI, US
Joseph Warmus - Ann Arbor MI, US

International Classification:

C07D285/14
C07D271/12
C07D249/08
A61K031/433
A61K031/4245
A61K031/4196

US Classification:

514363000, 514364000, 514383000, 548136000, 548143000, 548269400

Abstract:

This invention provides substituted Phenyl-(2-[1,3,4]thiadiazol-2-yl-phenyl)-amine and (2-[1,3,4]Oxadiazol-2-yl-phenyl)phenyl-amine compounds which act as inhibitors of MAPK/ERK Kinase (“MEK”) enzymes and pharmaceutical compositions and methods for their use in immunomodulation and in the treatment and alleviation of inflammation, and proliferative diseases such as cancer and restenosis.

US Patent:

20050020630, Jan 27, 2005

Filed:

Jun 3, 2004

Appl. No.:

10/860524

Inventors:

Michael Connolly - Ypsilanti MI, US
Rocco Gogliotti - Pinckney MI, US
Helen Lee - Ann Arbor MI, US
Mark Plummer - Dexter MI, US
Karen Sexton - Chelsea MI, US
Melean Visnick - Ann Arbor MI, US

International Classification:

C 07D 4 9/14
A61K031/454
A61K031/41

US Classification:

514320000, 514381000, 546196000, 548251000

Abstract:

The present invention provides benzo[b]thiophenes of Formula I: wherein R, R, R, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

US Patent:

20050049276, Mar 3, 2005

Filed:

Jul 20, 2004

Appl. No.:

10/896180

Inventors:

Michael Kaufman - Ypsilanti MI, US
Mark Plummer - Dexter MI, US
Gordon Rewcastle - Glendowie, NZ

International Classification:

C07D471/04
A61K031/4745

US Classification:

514303000, 546118000, 546119000

Abstract:

The present invention relates to imidazopyridine and triazolopyridine derivatives, pharmaceutical compositions and methods of use thereof.

US Patent:

20050059710, Mar 17, 2005

Filed:

Jul 22, 2004

Appl. No.:

10/896514

Inventors:

Stephen Barrett - Hartland MI, US
Michael Kaufman - Ypsilanti MI, US
Mark Plummer - Dexter MI, US
Jessica Reed - Ann Arbor MI, US
Bruce Roth - Plymouth MI, US
Kevin Schlosser - Ann Arbor MI, US

International Classification:

C07D213/46
A61K031/44
A61K031/401
A61K031/277
A61K031/135

US Classification:

514355000, 514524000, 514658000, 546315000, 548530000, 558410000, 564433000, 514423000

Abstract:

The present invention relates to diphenylamino ketone derivatives, pharmaceutical compositions and methods of use thereof.

US Patent:

20050124668, Jun 9, 2005

Filed:

Sep 24, 2004

Appl. No.:

10/949908

Inventors:

Christopher Deur - Ann Arbor MI, US
Kevin Henegar - Ann Arbor MI, US
Christine Kolz - Dexter MI, US
Jonathan Miller - Ann Arbor MI, US
Augastine Osuma - Canton MI, US
Mark Plummer - Dexter MI, US
Brian Samas - Ann Arbor MI, US
Jacob Schwarz - Ann Arbor MI, US
Andrew Thorpe - Whitmore Lake MI, US
David Wustrow - Ann Arbor MI, US

International Classification:

A61K031/44
C07D213/55
A61K031/277
A61K031/198

US Classification:

514357000, 514522000, 514567000, 514561000, 558410000, 562443000, 546335000

Abstract:

Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.