Mark R Pope

US Patent:

6468229, Oct 22, 2002

Filed:

Jan 26, 2001

Appl. No.:

09/529148

Inventors:

John P. Grace - Lake Villa IL
Neil W. Loomis - Racine WI
Thomas G. Schapira - Bristol WI
Sie Ting Wong - Mundelein IL
Kristin M. Noonan - Chicago IL
Michael G. Lowery - Wildwood IL
Pete M. Bojan - Grayslake IL
Daniel P. Schmidt - Bannockburn IL
Tung-Ming Huang - Buffalo Grove IL
Robert G. Hiltibran - late of Libertyville IL
Mark R. Pope - Grayslake IL
John J. Kotlarik - Lake Geneva WI
Brian Joseph Tarkowski - Lake Villa IL
David Dean Cunningham - Lake Villa IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 500

US Classification:

600573, 604317

Abstract:

The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.

US Patent:

6569157, May 27, 2003

Filed:

May 18, 1998

Appl. No.:

09/080432

Inventors:

Eric B. Shain - Glencoe IL
Mark R. Pope - Grayslake IL
Joseph L. Pezzaniti - Round Lake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 1820

US Classification:

606 12, 606 9, 606 10, 606 13

Abstract:

The invention involves a method for focusing light comprising the steps of: projecting at least one pulse of light onto the surface of the skin of a patient; collecting at least a portion of the light that is reflected from the skin of the patient; projecting the collected, reflected light onto a detector; and adjusting the projection of the pulsed light onto the surface of the skin of the patient in such a manner that the signal projected onto the detector is optimized. When the light pulse is properly focused, e. g. , when it is characterized by the best focus, it can be used to provide energy to form an opening in the skin of the patient. When more than one pulse of light is required to form an opening in the skin of the patient, aligning the light prior to each pulse will improve the efficiency of formation of the opening. In general, the method for aligning and focussing is the same as the method for focusing, with the difference being that aligning further includes steps for moving the spot of light formed by the light so that it strikes the surface of the skin at or near the position on the surface of the skin of the patient at which the previous spot of light struck the skin.

US Patent:

6679841, Jan 20, 2004

Filed:

Jun 15, 2001

Appl. No.:

09/880948

Inventors:

Peter M. Bojan - Grayslake IL
Timothy P. Henning - Vernon Hills IL
Neil W. Loomis - Racine WI
Mark R. Pope - Grayslake IL
Jonathan A. Eppstein - Atlanta GA

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 500

US Classification:

600309, 600310, 600345, 600584

Abstract:

An article capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article. Preferably, the article is also capable of measuring the amount of analyte in the interstitial fluid. The article can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid. In one preferred embodiment, the article is a multiple-layer element comprising: (1) a layer that is capable of being placed in contact with the skin of a patient; (2) a layer that is coated over the skin-contacting layer; (3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted; (5) a layer, disposed on the surface of the meter-contacting layer that faces the skin-contyacting layer, that is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid. In order to use the multiple-layer element, light from a source of light is transmitted through the opening in the multiple-layer material to be absorbed at a light-absorbing target on the skin-contacting layer. This light transfers energy to the target, and this transferred energy causes an opening to form in the skin-contacting layer and an opening to form in the stratum corneum.

US Patent:

6786874, Sep 7, 2004

Filed:

Sep 13, 2002

Appl. No.:

10/243584

Inventors:

John P. Grace - Lake Villa IL
Neil W. Loomis - Racine WI
Thomas G. Schapira - Bristol WI
Sie Ting Wong - Mundelein IL
Kristin M. Noonan - Chicago IL
Michael G. Lowery - Wildwood IL
Pete M. Bojan - Grayslake IL
Daniel P. Schmidt - Bannockburn IL
Tung-Ming Huang - Buffalo Grove IL
Robert G. Hiltibran - late of Libertyville IL
Mark R. Pope - Grayslake IL
John J. Kotlarik - Lake Geneva WI
Brian Joseph Tarkowski - Lake Villa IL
David Dean Cunningham - Lake Villa IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 1000

US Classification:

600573

Abstract:

The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.

US Patent:

51360276, Aug 4, 1992

Filed:

May 2, 1989

Appl. No.:

7/346508

Inventors:

Mark R. Pope - Wildwood IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07K 312

US Classification:

530427

Abstract:

A high concentration of renaturing surfactants is added to protein systems in the presence of alkyl sulfate detergents to displace the detergent with respect to the interaction with the protein, thereby renaturing the protein and restoring its reactivity. The presence of higher quantities of detergent in the system results in smaller protein aggregates, and thus a higher reactivity and specificity as measured for the system in its entirety.

US Patent:

62450603, Jun 12, 2001

Filed:

Dec 27, 1999

Appl. No.:

9/472695

Inventors:

Neil W. Loomis - Racine WI
Peter M. Bojan - Grayslake IL
Timothy P. Henning - Vernon Hills IL
Mark R. Pope - Grayslake IL
Andrew J. Muetterties - Mundelein IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 1818

US Classification:

606 9

Abstract:

A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of: (a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and (b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum. Preferably, exposure of the region of the stratum corneum to the source of light is ceased when an amount of interstitial fluid fills the opening in the stratum corneum, which amount is sufficient to cause the scatter intensity of the light reflected from the surface of the interstitial fluid occupying the opening in the stratum corneum to differ from the scatter intensity of the light reflected from a region of the stratum corneum that is substantially free of interstitial fluid. The invention also involves an apparatus for carrying out the foregoing method.

US Patent:

52722600, Dec 21, 1993

Filed:

Jan 29, 1992

Appl. No.:

7/827669

Inventors:

Mark R. Pope - Wildwood IL
Christopher Bieniarz - Highland Park IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07H 1524
C12Q 100

US Classification:

536 181

Abstract:

Novel pyrene-trisulfonate derivatives and the use thereof in a method for the determination of glycohydrolytic enzyme activity are provided. The method comprises the steps of (a) forming a test solution comprising a test sample containing the glycohydrolytic enzyme and a pyrene-trisulfonate derivative of the present invention, wherein the derivative is hydrolyzed by the glycohydrolytic enzyme to result in the formation of free 8-hydroxy-1,3,6-pyrene trisulfonate as a function of, and which can be correlated to, the amount of the glycohydrolytic enzyme present in the test sample, and (b) measuring and correlating either the intensity of fluorescence, or the optical density, of the test solution to the presence or amount of the glycohydrolytic enzyme in the test sample. A preferred pyrene-trisulfonate derivative is pyrene-1,3,6-trisulfonic acid) 8-. beta. -D-glucuronide for the determination of. beta.

US Patent:

53995015, Mar 21, 1995

Filed:

Mar 16, 1992

Appl. No.:

7/852837

Inventors:

Mark R. Pope - Wildwood IL
Kevin M. Knigge - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33549
G01N 33543
C12N 1106
C12N 1100

US Classification:

436532

Abstract:

A specific binding member such as an antigen or antibody is immobilized by covalent attachment to a solid phase such as a latex microparticle. The solid phase is reacted with a heterobifunctional or homobifunctional coupling agent to form a complex that is then reacted with a dithiol compound to form a thiolated solid phase. A specific binding member is reacted with the coupling agent to form a complex which is then reacted with the thiolated solid phase to link the specific binding member to the solid phase through thioethers. Alternatively, the dithiol compound may be reacted with the specific binding member/coupling agent complex to form a thiolated complex that is reacted with the solid phase/coupling agent complex. The coupling agent may contain a spacer. In another embodiment, the solid phase is reacted with a disulfide compound to form a complex and the complex is reacted with a reductant to form a thiolated solid phase which is reacted with a specific binding member/coupling agent complex.