Mark I Pope

US Patent:

6569157, May 27, 2003

Filed:

May 18, 1998

Appl. No.:

09/080432

Inventors:

Eric B. Shain - Glencoe IL
Mark R. Pope - Grayslake IL
Joseph L. Pezzaniti - Round Lake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61B 1820

US Classification:

606 12, 606 9, 606 10, 606 13

Abstract:

The invention involves a method for focusing light comprising the steps of: projecting at least one pulse of light onto the surface of the skin of a patient; collecting at least a portion of the light that is reflected from the skin of the patient; projecting the collected, reflected light onto a detector; and adjusting the projection of the pulsed light onto the surface of the skin of the patient in such a manner that the signal projected onto the detector is optimized. When the light pulse is properly focused, e. g. , when it is characterized by the best focus, it can be used to provide energy to form an opening in the skin of the patient. When more than one pulse of light is required to form an opening in the skin of the patient, aligning the light prior to each pulse will improve the efficiency of formation of the opening. In general, the method for aligning and focussing is the same as the method for focusing, with the difference being that aligning further includes steps for moving the spot of light formed by the light so that it strikes the surface of the skin at or near the position on the surface of the skin of the patient at which the previous spot of light struck the skin.

US Patent:

63128888, Nov 6, 2001

Filed:

Oct 16, 2000

Appl. No.:

9/688636

Inventors:

Sie Ting Wong - Mundelein IL
Robert G. Hiltibran - Bristol WI
Tung-Ming Huang - Buffalo Grove IL
Brenda B. Calfin - Chicago IL
Mark R. Pope - Grayslake IL
Thomas G. Schapira - Bristol WI
Eric B. Shain - Glencoe IL
Douglas F. Young - Grayslake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12Q 100

US Classification:

435 4

Abstract:

An article and a method for monitoring the concentration of an analyte, e. g. , glucose, in blood. In one aspect, the invention involves an article comprising a multiple-layer element. In one embodiment, the article comprises: a multiple-layer element comprising: (a) a base layer (b) a cover layer, the cover layer having a first opening for venting the multiple-layer element and a second opening for receiving a biological sample; and (c) a core layer having a first major surface and a second major surface, the core layer disposed between the base layer and the cover layer, the core layer comprising a sample introduction chamber and a optical reading chamber, the first major surface of the core layer in face-to-face contact with the base layer, the second major surface of the core layer in face-to-face contact with the cover layer. The multiple-layer element of this invention allows the use of samples of blood or other biological fluids, such as interstitial fluid, to provide extremely sensitive assay results. The device has been shown to provide accurate and reproducible results with samples having volumes ranging from about 5. mu.