Mark A Porter

US Patent:

7415358, Aug 19, 2008

Filed:

May 22, 2002

Appl. No.:

10/152319

Inventors:

Donna Mendrick - Gaithersburg MD, US
Mark Porter - Gaithersburg MD, US
Kory Johnson - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Arthur Castle - Gaithersburg MD, US
Michael Elashoff - Gaithersburg MD, US

Assignee:

Ocimum Biosolutions, Inc. - Indianapolis IN

International Classification:

G06F 19/00

US Classification:

702 19, 435 6, 700 30, 702 22, 7071041

Abstract:

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

US Patent:

7426441, Sep 16, 2008

Filed:

Jan 18, 2005

Appl. No.:

11/036196

Inventors:

Donna Mendrick - Gaithersburg MD, US
Mark Porter - Gaithersburg MD, US
Kory Johnson - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Arthur Castle - Gaithersburg MD, US
Michael Elashoff - Gaithersburg MD, US

Assignee:

Ocimum Biosolutions, Inc. - Indianapolis IN

International Classification:

G06F 19/00

US Classification:

702 19, 435 6, 700 30, 702 22, 7071041

Abstract:

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

US Patent:

7447594, Nov 4, 2008

Filed:

Jan 8, 2003

Appl. No.:

10/338044

Inventors:

Donna L. Mendrick - Gaithersburg MD, US
Mark W. Porter - Gaithersburg MD, US
Kory R. Johnson - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Arthur Castle - Gaithersburg MD, US
Michael Elashoff - Gaithersburg MD, US

Assignee:

Ocimum Biosolutions, Inc. - Indianapolis IN

International Classification:

G06F 19/00

US Classification:

702 19, 435 6, 700 30, 702 22, 7071041

Abstract:

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

US Patent:

7469185, Dec 23, 2008

Filed:

Feb 4, 2003

Appl. No.:

10/357507

Inventors:

Donna L. Mendrick - Gaithersburg MD, US
Mark W. Porter - Gaithersburg MD, US
Kory R. Johnson - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Arthur L. Castle - Gaithersburg MD, US
Michael Orr - Gaithersburg MD, US
Michael R. Elashoff - Gaithersburg MD, US

Assignee:

Ocimum Biosolutions, Inc. - Indianapolis IN

International Classification:

G06F 19/00

US Classification:

702 19, 435 6, 700 30, 702 22, 7071041

Abstract:

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

US Patent:

7590493, Sep 15, 2009

Filed:

Feb 17, 2005

Appl. No.:

11/059535

Inventors:

Donna Mendrick - Gaithersburg MD, US
Mark Porter - Gaithersburg MD, US
Kory Johnson - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Arthur Castle - Gaithersburg MD, US
Michael Elashoff - Gaithersburg MD, US

Assignee:

Ocimum Biosolutions, Inc. - Indianapolis IN

International Classification:

G06F 19/00

US Classification:

702 19, 435 6, 700 30, 702 22, 7071041

Abstract:

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

US Patent:

20040014040, Jan 22, 2004

Filed:

Jul 10, 2002

Appl. No.:

10/191803

Inventors:

Donna Mendrick - Gaithersburg MD, US
Mark Porter - Gaithersburg MD, US
Kory Johnson - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Arthur Castle - Gaithersburg MD, US
Michael Elashoff - Gaithersburg MD, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

US Patent:

20040043405, Mar 4, 2004

Filed:

Jul 17, 2003

Appl. No.:

10/620765

Inventors:

Arthur Castle - Gaithersburg MD, US
Brandon Higgs - Gaithersburg MD, US
Michael Elashoff - Gaithersburg MD, US
Mark Porter - Gaithersburg MD, US

Assignee:

Gene Logic, Inc.

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

The present invention includes methods of identifying genes whose expression level is invariant among cell or tissue types. The methods of the invention can be used in the diagnosis of disease, in quality control in evaluating external data or databases, and in normalization of external data for comparative purposes. The genes of the invention can be used to produce microarrays that generate data with improved reliability.

US Patent:

20040110193, Jun 10, 2004

Filed:

Aug 4, 2003

Appl. No.:

10/633306

Inventors:

Arthur Castle - Gaithersburg MD, US
Michael Elashoff - Gaithersburg MD, US
Kory Johnson - Gaithersburg MD, US
Mark Porter - Gaithersburg MD, US

Assignee:

Gene Logic, Inc.

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Methods for classification of biological data including the use of mathematically based classification models are disclosed. In preferred embodiments, gene expression data derived from biological studies is used to classify events. The methods use a version of a linear discriminate model for deriving markers according to a technique whereby the model is limited to scoring the predictive ability of genes without making assumptions about inter-gene relationships, relative magnitudes or redundant information. In an associated method for building a fully informative database of biological information, biological studies are performed on a continual basis and linear discriminate models are used to provide rapid and efficient updates to gene markers.