Mark T Pratt

US Patent:

6663785, Dec 16, 2003

Filed:

Mar 6, 2002

Appl. No.:

10/092018

Inventors:

Zhe Huang - Fremont CA
Mark A. Devito - Vancouver WA
Mike P. Grimshaw - Vancouver WA
Paul A. Crump - Portland OR
Jason N. Farmer - Seattle WA
Mark R. Pratt - Seattle WA

Assignee:

nLight Photonics Corporation - Seattle WA

International Classification:

B44C 122

US Classification:

216 2, 216 24, 372 23, 372 46, 372 50, 372 69, 438689

Abstract:

Embodiments of the present invention are directed to method of fabrication of a broadband emitter array. Embodiments of the present invention may grown a first set of emitters possessing a first quantum well characteristic (e. g. , quantum well thickness or composition). A portion of the first set of emitters is removed by etching. In place of the removed emitters, a second set of emitters is regrown with said second set of emitters possessing a different quantum well characteristic. By fabricating the emitters sets in this manner, a unitary emitter array may be fabricated that possesses an increased bandwidth, e. g. , the first and second sets of emitters may be associated with different center wavelengths. Embodiments of the present invention may utilize emitter arrays fabricated in this manner in, for example, incoherently beam combined (IBC) lasers and in Raman amplifier systems.

US Patent:

8241573, Aug 14, 2012

Filed:

Mar 30, 2007

Appl. No.:

12/295337

Inventors:

Saibal Banerjee - Hayward CA, US
Colin Barnes - Essex, GB
Kevin Benson - Essex, GB
Jason Bryant - Essex, GB
Dale Buermann - Los Altos CA, US
Sergey Etchin - Hayward CA, US
Johnny Ho - Hayward CA, US
Xavier Lee - Hayward CA, US
Peter Lundberg - Los Altos CA, US
Klaus Maisinger - Cambridge, GB
Bojan Obradovic - Essex, GB
Mark Pratt - Hayward CA, US
Mark Reed - Menlo Park CA, US
Chiara Rodighiero - Essex, GB
Subra Sankar - Hayward CA, US
Harold Swerdlow - Essex, GB
Eric Vermaas - Hayward CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

G01N 21/64
G06K 9/00
C12M 1/36

US Classification:

422 8205, 422 8208, 435 61, 435 911, 4352872, 382128, 382129

Abstract:

The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.

US Patent:

8359166, Jan 22, 2013

Filed:

Aug 31, 2009

Appl. No.:

12/551438

Inventors:

Mark R. Pratt - San Mateo CA, US
David P. Holden - Burlingame CA, US

Assignee:

Applied Biosystems, LLC - Carlsbad CA

International Classification:

G06F 19/00
G06F 15/00
G11C 17/00

US Classification:

702 20, 365 94, 700 1

Abstract:

Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model.

US Patent:

8436999, May 7, 2013

Filed:

Sep 26, 2008

Appl. No.:

12/679652

Inventors:

Mark Pratt - Belmont CA, US
Jason Bryant - Cambridge, GB

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

G01N 21/00

US Classification:

356432, 356435

Abstract:

A detection system for separately detecting different wavelengths of emission light emitted from a sample. The system includes a detection assembly to receive the emission light emitted from the sample. The detection assembly includes a multi-band dichroic member and at least first and second detection cameras. The multi-band dichroic member has a transmission/reflection characteristic with at least two transmissive regions separated from each other along a wavelength spectrum and with at least one reflective region separated from the transmissive regions along the wavelength spectrum. The dichroic member transmits portions of the emission light that align with the at least two transmissive regions to the first detection camera. The dichroic member reflects a portion of the emission light that aligns with the reflective region to the second detection camera.

US Patent:

20060024690, Feb 2, 2006

Filed:

Mar 22, 2005

Appl. No.:

11/086260

Inventors:

H. Kao - Fremont CA, US
Ian Harding - San Mateo CA, US
Kathleen Hayashibara - Campbell CA, US
Achim Karger - Foster City CA, US
Fiona Laird Hyland - San Mateo CA, US
Mark Oldham - Los Gatos CA, US
Omead Ostadan - San Leandro CA, US
Mark Pratt - San Mateo CA, US
Junko Stevens - Menlo Park CA, US
Austin Tomaney - San Francisco CA, US
Greg Young - Menlo Park CA, US

International Classification:

C12Q 1/68
G06F 19/00
G01N 33/48
G01N 33/50

US Classification:

435006000, 702020000

Abstract:

A method of using a standard to correct for variability in sample handling, can comprise (a) adding a template of known concentration to an assay comprising a sample; (b) preamplifying the assay; (c) amplifying the assay; (d) collecting data during the amplifying; and (e) correcting the data using a comparison of data collected from the template to data collected from the sample.

US Patent:

20060134662, Jun 22, 2006

Filed:

Oct 25, 2005

Appl. No.:

11/259162

Inventors:

Mark Pratt - San Mateo CA, US
David Holden - Burlingame CA, US

International Classification:

C12Q 1/68
G06F 19/00

US Classification:

435006000, 702020000

Abstract:

Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model.

US Patent:

20080033677, Feb 7, 2008

Filed:

Jun 11, 2007

Appl. No.:

11/761236

Inventors:

Austin Tomaney - San Francisco CA, US
David Holden - Burlingame CA, US
Mark Pratt - San Mateo CA, US
H. Kao - Fremont CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

G06F 19/00

US Classification:

702085000, 359893000

Abstract:

An embodiment generally relates to a method of processing signals. The method includes providing for a plurality of filters, where each filter is configured to process an associated dye. The method also includes determining a residual error for at least one filter during dye amplification and modifying the at least one filter based on the residual error. The method further includes filtering subsequent signals associated with the modified at least one filter.

US Patent:

20100113285, May 6, 2010

Filed:

Apr 28, 2009

Appl. No.:

12/431685

Inventors:

H. Pin Kao - Fremont CA, US
Ian A. Harding - San Mateo CA, US
Kathleen C. Hayashibara - Cupertino CA, US
Achim Karger - Foster City CA, US
Fiona C. Laird Hyland - San Mateo CA, US
Mark F. Oldham - Los Gatos CA, US
Omead Ostadan - San Leandro CA, US
Mark R. Pratt - San Mateo CA, US
Junko F. Stevens - Menio Park CA, US
Austin B. Tomaney - San Francisco CA, US
Greg Young - Menlo Park CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

C40B 30/00
C12Q 1/68

US Classification:

506 7, 435 6

Abstract:

A method of using a standard to correct for variability in sample handling, can comprise (a) adding a template of known concentration to an assay comprising a sample; (b) preamplifying the assay; (c) amplifying the assay; (d) collecting data during the amplifying; and (e) correcting the data using a comparison of data collected from the template to data collected from the sample.