Mark Evans Reed

US Patent:

8173080, May 8, 2012

Filed:

Feb 14, 2008

Appl. No.:

12/031054

Inventors:

Michal Lebl - San Diego CA, US
Dale Buermann - Los Altos CA, US
Mark T. Reed - Menlo Park CA, US
David L. Heiner - San Diego CA, US
Alexander Triener - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

B01L 3/00

US Classification:

422503, 422 50, 422500, 422501, 422502, 436180, 204450

Abstract:

A flows cell for use in a microfluidic detection system is provided. The flow cell includes a flows cell body having a channel that is configured to convey a solution through the flows cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.

US Patent:

8252250, Aug 28, 2012

Filed:

Nov 25, 2009

Appl. No.:

12/626353

Inventors:

Jonathan Posner - Tempe AZ, US
Kamil Salloum - Tempe AZ, US
Michal Lebl - San Diego CA, US
Mark Reed - San Diego CA, US
Dale Buermann - San Diego CA, US
Matthew Hage - San Diego CA, US
Bryan Crane - San Diego CA, US
David Heiner - San Diego CA, US
Robert Kain - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA
The Arizona Board of Regents for and on behalf of Arizona State University - Scottsdale AZ

International Classification:

B01L 3/00

US Classification:

422505, 422 50, 422513, 417 32

Abstract:

An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir.

US Patent:

8597594, Dec 3, 2013

Filed:

Jul 18, 2012

Appl. No.:

13/551704

Inventors:

Jonathan Posner - Seattle WA, US
Kamil Salloum - Portland OR, US
Michal Lebl - San Diego CA, US
Mark Reed - San Diego CA, US
Dale Buermann - San Diego CA, US
Matthew Hage - San Diego CA, US
Bryan Crane - San Diego CA, US
David Heiner - San Diego CA, US
Robert Kain - San Diego CA, US
Michael Schroeder - Chandler AZ, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

B01L 3/00

US Classification:

422505, 422 50, 422501, 422502, 422503, 422504, 436180, 429405, 429409

Abstract:

An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.

US Patent:

20120022821, Jan 26, 2012

Filed:

Jul 23, 2010

Appl. No.:

12/842743

Inventors:

Paul Dembiczak - Washougal WA, US
Mark John Reed - Camas WA, US
Wei Seng Chew - Singapore, SG

International Classification:

G06F 19/00

US Classification:

702120

Abstract:

A system including an integrated circuit configured to transfer a mission mode signal between a mission mode circuit on the integrated circuit and a first input/output pin on the integrated circuit in mission mode and to transfer a development mode signal between a development mode circuit on the integrated circuit and the first input/output pin in debug mode. The integrated circuit is configured to transfer the mission mode signal between the mission mode circuit and a second input/output pin on the integrated circuit in debug mode.

US Patent:

20120195794, Aug 2, 2012

Filed:

Apr 9, 2012

Appl. No.:

13/442013

Inventors:

Michal Lebl - San Diego CA, US
Dale Buermann - Los Altos CA, US
Mark T. Reed - Menlo Park CA, US
David L. Heiner - San Diego CA, US
Alexander Triener - San Diego CA, US

Assignee:

Illumina, Inc - San Diego CA

International Classification:

G01N 33/48
B01L 3/00

US Classification:

422 63, 422505

Abstract:

A flow cell for use in a microfluidic detection system is provided. The flow cell includes a flow cell body having a channel that is configured to convey a solution through the flow cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.

US Patent:

20140080205, Mar 20, 2014

Filed:

Nov 20, 2013

Appl. No.:

14/085122

Inventors:

Michal Lebl - San Diego CA, US
Mark Reed - San Diego CA, US
Dale Buermann - San Diego CA, US
Matthew Hage - San Diego CA, US
Bryan Crane - San Diego CA, US
David Heiner - San Diego CA, US
Robert Kain - San Diego CA, US
Michael Schroeder - Chandler AZ, US

Assignee:

THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY - Scottsdale AZ
ILLUMINA, INC. - San Diego CA

International Classification:

F04B 37/10

US Classification:

4352873, 422 8205

Abstract:

An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.

US Patent:

20220226819, Jul 21, 2022

Filed:

Apr 5, 2022

Appl. No.:

17/714129

Inventors:

- San Diego CA, US
Bryan Crane - San Diego CA, US
Patrick Leung - San Bruno CA, US
Drew Verkade - Carlsbad CA, US
Mark Reed - Menlo Park CA, US

International Classification:

B01L 3/00
B01L 9/00
G01N 21/05

Abstract:

A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

US Patent:

20200290043, Sep 17, 2020

Filed:

May 14, 2020

Appl. No.:

16/874412

Inventors:

- San Diego CA, US
Bryan Crane - San Diego CA, US
Patrick Leung - San Bruno CA, US
Drew Verkade - Carlsbad CA, US
Mark Reed - Menlo Park CA, US

International Classification:

B01L 3/00
B01L 9/00
G01N 21/05

Abstract:

A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.