Mark D Roth

US Patent:

8110352, Feb 7, 2012

Filed:

Feb 10, 2006

Appl. No.:

11/883694

Inventors:

Mark J. Roth - Chevy Chase MD, US
Konrad Huppi - Herndon VA, US

Assignee:

The United States of America as represented by the Secretary, Department of Health & Human Services - Washington DC

International Classification:

C12Q 1/68
G01N 33/574

US Classification:

435 61, 435 721, 435 723

Abstract:

The invention relates to method of diagnosing and treating cancer, in particular β-catenin related cancers. The invention further relates to methods of identifying CTNNB1 related cancer CTNNB1 therapeutics.

US Patent:

20120294929, Nov 22, 2012

Filed:

Jan 3, 2012

Appl. No.:

13/342877

Inventors:

Mark J. Roth - Bethesda MD, US
Konrad Huppi - Herndon VA, US

Assignee:

Health & Human Services - NIH - Bethesda MD

International Classification:

G01N 33/574
C12N 15/113
C40B 30/06
A61P 35/00
C12Q 1/68
A61K 31/713
A61K 9/127

US Classification:

424450, 514 44 A, 536 245, 435 612, 435 71, 435 611, 435 614, 435 613, 506 10

Abstract:

The invention relates to method and compositions for treating and diagnosing cancer, in particular β-catenin related cancers. In general, the methods include administering RNAi constructs. The invention further relates to methods of identifying CTNNB1 related cancer therapeutics.

US Patent:

60209690, Feb 1, 2000

Filed:

Jul 11, 1997

Appl. No.:

8/893505

Inventors:

Andrew D. Struckhoff - Alexandria VA
Lee C. Cramer - Springfield VA
Steven F. Spiers - Richmond VA
Gordon H. Bokelman - Chesterfield VA
Bogdan N. Alexander - Richmond VA
Mark Roth - Annandale VA

Assignee:

Philip Morris Incorporated - New York NY

International Classification:

G01N 2189

US Classification:

356430

Abstract:

An optical inspection system mounts on a cigarette making machine or like system and detects the presence of bands having irregular widths or spacings. In response to the detection of irregular bands, the optical inspection system instructs the cigarette making machine to reject cigarettes which will be subsequently made from portions of the cigarette paper containing the irregular bands. The optical inspection system includes a sensor which can accommodate different types of cigarette paper and band material having varying reflectance properties. In operation, sensor circuitry detects the range of voltages produced by a sensor detector, and formulates a peak value (or average peak value) for the range of voltages. The circuitry then takes a percentage of this peak value to form a threshold value. This threshold value is compared with the AC signal from the sensor detector.

US Patent:

58436448, Dec 1, 1998

Filed:

Mar 1, 1994

Appl. No.:

8/203780

Inventors:

Lance A. Liotta - Potomac MD
Zhengping Zhuang - Rockville MD
Michael R. Buck - Bethesda MD
William G. Stetler-Stevenson - Silver Spring MD
Irina A. Lubensky - Silver Spring MD
Mark J. Roth - Silver Spring MD

Assignee:

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

A method of direct extraction of cellular material from a tissue sample which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extracted zone(s) of cells is subjected to analysis. The overall process of identifying, extracting, transporting, and analyzing the extracted zones(s) of cells can be fully automated.