Mark Brantly Roth

US Patent:

6596501, Jul 22, 2003

Filed:

Feb 23, 1999

Appl. No.:

09/256497

Inventors:

Mark Roth - Seattle WA

Assignee:

Fred Hutchinson Cancer Research Center - Seattle WA

International Classification:

G01N 33543

US Classification:

435 721, 435 795, 436506, 436508, 436515, 436518

Abstract:

The present invention relates to diagnostic applications. For autoimmune diseases more particularly, it is demonstrated herein that individuals with SLE, APLA, MCDS and PSS have antibodies that are specific for SR proteins. Thus, in particular aspects the present invention provides methods and compositions for diagnosing autoimmune disease using SR proteins and antibodies to detect the presence of SR protein-specific antibodies in an individual suspected of having autoimmune disease, wherein the presence of such antibodies is indicative of said individual suffering from autoimmune disease.

US Patent:

7776547, Aug 17, 2010

Filed:

Dec 30, 2004

Appl. No.:

11/027470

Inventors:

Mark Roth - Seattle WA, US
Andrew Berlin - San Jose CA, US
Selena Chan - Sunnyvale CA, US
Xing Su - Cupertino CA, US
Lei Sun - Santa Clara CA, US

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

G01N 33/53

US Classification:

435 71, 436524, 436 8

Abstract:

Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.

US Patent:

7993681, Aug 9, 2011

Filed:

Oct 22, 2004

Appl. No.:

10/972063

Inventors:

Mark B. Roth - Seattle WA, US

Assignee:

Fred Hutchinson Cancer Research Center - Seattle WA

International Classification:

A01N 59/02
A01N 1/00

US Classification:

424708, 435 11

Abstract:

The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.

US Patent:

20050053912, Mar 10, 2005

Filed:

Jun 10, 2002

Appl. No.:

10/480430

Inventors:

Mark Roth - Seattle WA, US
Pamela Padilla - Seattle WA, US

International Classification:

A01N001/00
C12N005/02
C12Q001/00

US Classification:

435004000, 514001000, 435001300, 435374000

Abstract:

The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.

US Patent:

20050136125, Jun 23, 2005

Filed:

Oct 22, 2004

Appl. No.:

10/971575

Inventors:

Mark Roth - Seattle WA, US

International Classification:

A01N043/62
A61K051/00
A61K033/00

US Classification:

424600000, 514492000, 514706000, 424607000

Abstract:

The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer is provided.

US Patent:

20050170019, Aug 4, 2005

Filed:

Oct 22, 2004

Appl. No.:

10/971576

Inventors:

Mark Roth - Seattle WA, US

International Classification:

A61K033/04

US Classification:

424705000, 435002000

Abstract:

The present invention concerns the use of oxygen antagonists for inducing stasis in cells. It includes methods and apparatuses for achieving stasis in cells, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for storing platelets is provided.

US Patent:

20060009914, Jan 12, 2006

Filed:

Aug 16, 2004

Appl. No.:

10/919699

Inventors:

Narayan Sundararajan - San Francisco CA, US
Lei Sun - Santa Clara CA, US
Xing Su - Cupertino CA, US
Mineo Yamakawa - Campbell CA, US
Zhang Jingwu - San Jose CA, US
Selena Chan - San Jose CA, US
Andrew Berlin - San Jose CA, US
Mark Roth - Seattle WA, US
Phil Gafken - Seattle WA, US

International Classification:

G06F 19/00
G01N 33/48

US Classification:

702019000, 702020000

Abstract:

Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modifications to nucleic acids, proteins, and peptides using SERS and Raman spectroscopy. Applications of embodiments of the present invention include proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.

US Patent:

20060134714, Jun 22, 2006

Filed:

Aug 11, 2005

Appl. No.:

11/202862

Inventors:

Narayan Sundararajan - San Francisco CA, US
Lei Sun - Santa Clara CA, US
Xing Su - Cupertino CA, US
Mineo Yamakawa - Campbell CA, US
Zhang Jingwu - San Jose CA, US
Selena Chan - San Jose CA, US
Andrew Berlin - San Jose CA, US
Mark Roth - Seattle WA, US
Phil Gafken - Seattle WA, US

International Classification:

C12Q 1/48
C12Q 1/34

US Classification:

435015000, 435018000

Abstract:

Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.