Mark T Roth

US Patent:

20060009914, Jan 12, 2006

Filed:

Aug 16, 2004

Appl. No.:

10/919699

Inventors:

Narayan Sundararajan - San Francisco CA, US
Lei Sun - Santa Clara CA, US
Xing Su - Cupertino CA, US
Mineo Yamakawa - Campbell CA, US
Zhang Jingwu - San Jose CA, US
Selena Chan - San Jose CA, US
Andrew Berlin - San Jose CA, US
Mark Roth - Seattle WA, US
Phil Gafken - Seattle WA, US

International Classification:

G06F 19/00
G01N 33/48

US Classification:

702019000, 702020000

Abstract:

Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modifications to nucleic acids, proteins, and peptides using SERS and Raman spectroscopy. Applications of embodiments of the present invention include proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.

US Patent:

20060134714, Jun 22, 2006

Filed:

Aug 11, 2005

Appl. No.:

11/202862

Inventors:

Narayan Sundararajan - San Francisco CA, US
Lei Sun - Santa Clara CA, US
Xing Su - Cupertino CA, US
Mineo Yamakawa - Campbell CA, US
Zhang Jingwu - San Jose CA, US
Selena Chan - San Jose CA, US
Andrew Berlin - San Jose CA, US
Mark Roth - Seattle WA, US
Phil Gafken - Seattle WA, US

International Classification:

C12Q 1/48
C12Q 1/34

US Classification:

435015000, 435018000

Abstract:

Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.