Mark Almeron Sanders

US Patent:

6784982, Aug 31, 2004

Filed:

Nov 4, 1999

Appl. No.:

09/434027

Inventors:

Martin Blumenfeld - Minneapolis MN
Joseph J. Talghader - Eden Prairie MN
Mark A. Sanders - Minneapolis MN

Assignee:

Regents of the University of Minnesota - Minneapolis MN

International Classification:

G06K 974

US Classification:

356 71

Abstract:

A device for detecting the pattern of polynucleic acid hybridization to a surface, the device includes (a) a positioning device for receiving a nucleic acid chip and keeping the chip in a sampling position, the nucleic acid chip being an object with a flat sample surface and an opposed surface that is joined to the sample surface by a thickness, with the sample surface having sequences of nucleic acids immobilized thereto, with each sequence being immobilized to a particular chip address. And, (b) an electronic light detector array, the detector array comprising detector pixels, the detector pixels being sensors located at particular detector pixel addresses, wherein the sampling position places the sample surface of the chip at a well-defined position relative to the electronic light detector array so that light leaving a chip address is substantially directed onto at least one detector pixel with an address that is correlated to the chip address.

US Patent:

6867851, Mar 15, 2005

Filed:

Aug 2, 2002

Appl. No.:

10/211113

Inventors:

Martin Blumenfeld - Minneapolis MN, US
Joseph J. Talghader - Eden Prairie MN, US
Mark A. Sanders - Minneapolis MN, US
Scott A. Nelson - Eagan MN, US
Kraig Anderson - Woburn MA, US
Steven A. Lewis - Bloomington MN, US

Assignee:

Regents of the University of Minnesota - Minneapolis MN

International Classification:

G01N021/03

US Classification:

356 73

Abstract:

An image detection apparatus comprises a light source and a holding apparatus adapted to hold a substrate on which a biological sample may be mounted. Light from the light source impinges on the biological sample and causes light that is representative of the sample to be emitted from the sample. A light detector is positioned in the path of the emitted light and is scanned across the emitted light. The emitted light may be focused on the light detector with an optical assembly. The emitted light may be generated by chromophores on probes in the biological sample.

US Patent:

7145645, Dec 5, 2006

Filed:

May 10, 2001

Appl. No.:

09/852375

Inventors:

Martin Blumenfeld - Minneapolis MN, US
Mark A. Sanders - Minneapolis MN, US
Joseph J. Talghader - Eden Prairie MN, US
Jesse R. Grenz - Minneapolis MN, US

Assignee:

Regents of the University of Minnesota - Minneapolis MN

International Classification:

G01N 21/03

US Classification:

356 73

Abstract:

A system and method using an electronic light detector array, e. g. , a CCD or a CMOS-based detector array, is used to acquire a visual image of a biological sample that includes biological material associated with a biological material holding structure (e. g. , a DNA spot array on a DNA chip, protein bands in a 2-D gel, etc. ). For example, fluorescence from a biological sample may be detected.

US Patent:

20070121111, May 31, 2007

Filed:

Dec 4, 2006

Appl. No.:

11/566594

Inventors:

Martin Blumenfeld - Minneapolis MN, US
Mark Sanders - Minneapolis MN, US
Joseph Talghader - Eden Prairie MN, US
Jesse Grenz - Minneapolis MN, US

International Classification:

G01J 3/30
G01N 21/25

US Classification:

356318000, 356417000

Abstract:

A system and method using an electronic light detector array, e.g., a CCD or a CMOS-based detector array, is used to acquire a visual image of a biological sample that includes biological material associated with a biological material holding structure (e.g., a DNA spot array on a DNA chip, protein bands in a 2-D gel, etc.). For example, fluorescence from a biological sample may be detected.

US Patent:

20110045565, Feb 24, 2011

Filed:

Aug 18, 2009

Appl. No.:

12/543226

Inventors:

Mark Sanders - Falcon Heights MN, US
Hermann Ulbrich - Bad Schoenborn, DE

Assignee:

LEICA BIOSYSTEMS NUSSLOCH GMBH - Nussloch

International Classification:

C12N 13/00
C12M 1/42

US Classification:

4351731, 4352891

Abstract:

A tissue infiltration apparatus, system and method are described, allowing accelerating infiltration of the tissue sample with a variety of reagents fluids. The apparatus comprises a reaction chamber adapted to receive a tissue sample and a dielectric fluid to be infiltrated into a tissue sample. The reaction chamber comprises a bottom and a circumferential wall with a window section that is transparent for microwave irradiation. A holding element holds the tissue sample over a predetermined time period at a distance of 3PD of the dielectric fluid from the window section is provided. PD is the penetration depth of the microwaves into the dielectric fluid and defined as the depth where the initial microwave field intensity has been reduced to 1/e. A microwave system irradiates microwave irradiation through the window section into the reaction chamber.

US Patent:

20110086417, Apr 14, 2011

Filed:

May 21, 2009

Appl. No.:

12/993730

Inventors:

Barnet Liberman - New York NY, US
Mark Sanders - Minneapolis MN, US

International Classification:

A01N 1/00

US Classification:

4352841

Abstract:

Apparatus and method for freezing biopsy material. The apparatus includes a container that includes an inner wall and an outer wall defining a space therebeween for receiving a material adapted to withstand a temperature below −20 F. The apparatus further includes a cooling insulating medium that is disposed between the inner wall and the outer wall, a biopsy holding section that is disposed in the cavity and that is configured for holding the biopsy material, and a brine solution that is disposed in the cavity such that the biopsy material held in the biopsy holding section is completed submerged in the brine solution.