Mark C Smedley

US Patent:

6375985, Apr 23, 2002

Filed:

Mar 8, 1999

Appl. No.:

09/583089

Inventors:

David C. Bomberger - Belmont CA
Paul G. Catz - Palo Alto CA
Mark I. Smedley - Foster City CA
Paul C. Stearns - Redwood City CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 914

US Classification:

424489, 424425, 514772, 514779, 514789

Abstract:

Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.

US Patent:

7087245, Aug 8, 2006

Filed:

Apr 22, 2002

Appl. No.:

10/128147

Inventors:

David C. Bomberger - Belmont CA, US
Paul G. Catz - Palo Alto CA, US
Mark I. Smedley - Foster City CA, US
Paul C. Stearns - Redwood City CA, US

International Classification:

A61K 9/14
A61K 9/66
A61K 9/00

US Classification:

424489, 424455, 424 45, 424 43

Abstract:

Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.

US Patent:

58797122, Mar 9, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/480624

Inventors:

David C. Bomberger - Belmont CA
Paul G. Catz - Palo Alto CA
Mark I. Smedley - Foster City CA
Paul C. Stearns - Redwood City CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 914

US Classification:

424489

Abstract:

Method of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug in a second mixing chamber. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.