Mark D Wolf

US Patent:

20200354353, Nov 12, 2020

Filed:

Nov 19, 2018

Appl. No.:

16/765315

Inventors:

- Menlo Park CA, US
Graham Johnson - Sanbornton NH, US
David Douglas Manning - Orchard Park NY, US
Mark Allan Wolf - Williamsville NY, US

Assignee:

ARIAGEN, INC. - Menlo Park CA

International Classification:

C07D 417/14
C07D 417/06
C07D 401/06
C07D 209/12
C07D 209/26
C07D 403/06
C07D 413/14
A61P 35/00

Abstract:

The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.

US Patent:

20160264579, Sep 15, 2016

Filed:

Nov 6, 2014

Appl. No.:

15/034905

Inventors:

- Osaka, JP
Jun TAKEUCHI - Osaka, JP
Tomoko YASUHIRO - Osaka, JP
Mark Allan WOLF - Williamsville NY, US
Vijay Dattaram PAWAR - Choa Chu Kang, SG
Anjan CHAKRABARTI - Dover, SG
Santhosh Kumar CHITTIMALLA - Clementi, SG

Assignee:

ONO PHARMACEUTICAL CO., LTD. - Osaka

International Classification:

C07D 487/04

Abstract:

A compound represented by the general formula (1) has a pyridone ring structure introduced into a pyrrolo pyrimidine skeleton, so that the compound has a strong Axl inhibitory activity. Consequently, the compound can be used as a therapeutic agent for Axl-related diseases including cancers such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.

Address:

851 Lakeside Dr, Corfu, NY 14036

Phone:

5853560792

VIN:

1G1ZC5E15BF233393

Make:

CHEVROLET

Model:

MALIBU

Year:

2011