Mark J Zamoyski

US Patent:

6342520, Jan 29, 2002

Filed:

Oct 30, 2000

Appl. No.:

09/699913

Inventors:

Mark Zamoyski - San Jose CA 95123

International Classification:

A61K 31335

US Classification:

514450, 514452, 514453, 514456, 514460, 514475, 604187

Abstract:

Sesquiterpenoid compounds and method for using such compounds to inhibit proliferation of malignant cells without inducing appreciable systemic cytotoxicity are disclosed. The compositions and methods presented also greatly reduce the duration of administration regimens compared to prior art and provide novel synergistic uses in combination with prior art chemotherapeutics.

US Patent:

6346251, Feb 12, 2002

Filed:

Sep 26, 2001

Appl. No.:

09/965483

Inventors:

Mark Zamoyski - San Jose CA 95123

International Classification:

A61K 3578

US Classification:

42419515, 424401, 42419516

Abstract:

Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to inhibit proliferation of psoriatic cell populations in the epidermis are disclosed.

US Patent:

6355251, Mar 12, 2002

Filed:

Sep 26, 2001

Appl. No.:

09/965198

Inventors:

Mark Zamoyski - San Jose CA 95123

International Classification:

A61K 3578

US Classification:

42419515, 42419516, 424401

Abstract:

Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to chemexfoliate selected epidermal cell populations are disclosed.

US Patent:

6468247, Oct 22, 2002

Filed:

Apr 21, 2000

Appl. No.:

09/557188

Inventors:

Mark Zamoyski - San Jose CA 95123

International Classification:

A61M 3700

US Classification:

604131, 606 1

Abstract:

A device for localized delivery of drugs into a user definable, three dimensional area within a tissue mass comprising a means for securely housing a plurality of hypodermic needles, a means of impaling and retracting the hypodermics into a tissue mass, and a means of injecting the contents of the hypodermics as they are being retracted.

US Patent:

6486146, Nov 26, 2002

Filed:

Nov 16, 2001

Appl. No.:

09/991427

Inventors:

Mark Zamoyski - San Jose CA 95123

International Classification:

A61K 3156

US Classification:

514177, 514651

Abstract:

The invention discloses compositions and methods for increasing chemotherapeutic specificity to endocrine dependent cancers, and reducing systemic toxicity, through administration of endocrine hormones in conjunction with administration of phase specific chemotherapeutics. The invention also discloses why prior art phase specific chemotherapeutic regimens fail to achieve high cure rates for cancer. The failure relates to the Gompertzian acceleration, or reduction in cancer cell cycle time, induced by the chemotherapeutic reduction of tumor size, which in turn results in the cancers lack of phase synchronicity to subsequent administrations of the phase specific chemotherapeutic(s). The invention discloses how to avoid this failure in endocrine dependent cancers by using endocrine blockers between chemotherapeutic administrations to halt the cancer cells from passing the S-Phase and then using endocrine hormones to restart and accelerate S-Phase progression in conjunction with administration of appropriate phase specific chemotherapeutic(s).

US Patent:

6559178, May 6, 2003

Filed:

Jan 29, 2002

Appl. No.:

10/059653

Inventors:

Mark Zamoyski - San Jose CA 95123

International Classification:

A61K 3135

US Classification:

514453, 514449, 514451, 514450

Abstract:

Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to achieve apoptotic ablation of internal organs or internal non-malignant cell populations are disclosed.

US Patent:

7012091, Mar 14, 2006

Filed:

Oct 25, 2003

Appl. No.:

10/694236

Inventors:

Mark Zamoyski - San Jose CA, US

International Classification:

A61K 31/335

US Classification:

514450, 514452, 514453, 514456, 514460, 514475

Abstract:

Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation to inhibit inflammatory responses in the respiratory tract are disclosed.

US Patent:

7015244, Mar 21, 2006

Filed:

Oct 30, 2003

Appl. No.:

10/696863

Inventors:

Mark Zamoyski - San Jose CA, US

International Classification:

A61I 31/35
A61K 31/335

US Classification:

514453, 449451, 449450, 449452, 449456, 449460, 449475

Abstract:

Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation for chemical debridement of cells in the lungs of COPD patients are disclosed.