Martha L Garrity from Beaverton, OR, age 64

Resumes

Martha Garrity

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Industry:

Biotechnology

Lawyers & Attorneys

Martha Garrity - Lawyer

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ISLN:

917325609

Admitted:

1995

Law School:

University of Washington School of Law, JD - Juris Doctor

Us Patents

Chemiluminescent Compounds And Use Thereof
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US Patent:

6723851, Apr 20, 2004
Filed:

Oct 31, 2001
Appl. No.:

09/999700
Inventors:

Phillip Miller - Dana Point CA
Martha Garrity - San Clemente CA
Assignee:

Quest Diagnostics Investment Incorporated - Wilmington DE
International Classification:

C07L 1702
US Classification:

546104, 435 75, 435 795, 546102
Abstract:

A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and detecting the novel compound.

Hydrophilic Chemilumescent Acridinium Labeling Reagents
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US Patent:

6924154, Aug 2, 2005
Filed:

Aug 20, 2002
Appl. No.:

10/225084
Inventors:

Ramon Evangelista - Laguna Hills CA, US
Martha Garrity - San Clemente CA, US
Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE
International Classification:

G01N033/533
C07K017/02
C07D219/04
C07D219/02
C09B015/00
US Classification:

436546, 435 6, 436500, 436526, 436544, 5303915, 546102, 546104
Abstract:

In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached to an antibody at higher loading before precipitation and aggregation problems are encountered. Additional compounds described herein contain linkers derived from short peptides and tetraethylene oxide which increase aqueous solubility due to hydrogen bonding with water molecules. The present invention also embraces reagents for multiple acridinium labeling for signal amplification composed of a peptide bearing several acridinium esters with sulfonate groups at regularly spaced intervals for increased solubility. The invention also embraces assays employing the above-described compounds.

Chemiluminescent Compounds And Use Thereof
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US Patent:

6994980, Feb 7, 2006
Filed:

Mar 22, 2004
Appl. No.:

10/805838
Inventors:

Phillip P. Miller - Dana Point CA, US
Martha Garrity - San Clemente CA, US
Assignee:

Quest Diagnostics Investments Inc. - Wilmington DE
International Classification:

G01N 33/53
G01N 33/535
G01N 33/543
G01N 33/533
C07D 219/00
US Classification:

435 71, 435 79, 435 791, 435 795, 436518, 436546, 546102, 546104
Abstract:

A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and detecting the novel compound.

Vitamin D Assay
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US Patent:

7087395, Aug 8, 2006
Filed:

Jan 16, 2001
Appl. No.:

09/761969
Inventors:

Martha Garrity - San Clemente CA, US
Jacqueline Tran - Westminster CA, US
Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE
International Classification:

G01N 33/53
G01N 33/543
G01N 21/00
US Classification:

435 793, 435 71, 435 79, 435 792, 436501, 436518, 436536, 436542, 422 61, 424 149, 536 231, 536 243, 536 2433
Abstract:

The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition. The releasing composition comprises an aqueous base component. In one embodiment, the releasing composition is substantially free from an organic solvent.

Hydrophilic Chemiluminescent Acridinium Labeling Reagents
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US Patent:

7297555, Nov 20, 2007
Filed:

Jul 14, 2005
Appl. No.:

11/181531
Inventors:

Ramon Evangelista - Laguna Hills CA, US
Martha Garrity - San Clemente CA, US
Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE
International Classification:

G01N 33/533
G01N 33/532
G01N 21/76
G01N 33/53
C07D 219/02
C07D 219/04
US Classification:

436546, 436544, 436172, 436800, 435 71, 435968, 546102, 546104
Abstract:

In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached to an antibody at higher loading before precipitation and aggregation problems are encountered. Additional compounds described herein contain linkers derived from short peptides and tetraethylene oxide which increase aqueous solubility due to hydrogen bonding with water molecules. The present invention also embraces reagents for multiple acridinium labeling for signal amplification composed of a peptide bearing several acridinium esters with sulfonate groups at regularly spaced intervals for increased solubility. The invention also embraces assays employing the above-described compounds.

Hydrophilic Chemiluminescent Acridinium Labeling Reagents
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US Patent:

7824928, Nov 2, 2010
Filed:

Nov 7, 2007
Appl. No.:

11/936703
Inventors:

Ramon Evangelista - Laguna Hills CA, US
Martha Garrity - San Clemente CA, US
Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE
International Classification:

G01N 33/533
G01N 33/532
G01N 21/76
G01N 33/53
C07D 219/02
C07D 219/04
US Classification:

436546, 436544, 436172, 435 71, 546102, 546104
Abstract:

In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached to an antibody at higher loading before precipitation and aggregation problems are encountered. Additional compounds described herein contain linkers derived from short peptides and tetraethylene oxide which increase aqueous solubility due to hydrogen bonding with water molecules. The present invention also embraces reagents for multiple acridinium labeling for signal amplification composed of a peptide bearing several acridinium esters with sulfonate groups at regularly spaced intervals for increased solubility. The invention also embraces assays employing the above-described compounds.

Hydrophilic Chemiluminescent Acridinium Labeling Reagents
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US Patent:

8034636, Oct 11, 2011
Filed:

Sep 23, 2010
Appl. No.:

12/889277
Inventors:

Ramon Evangelista - Laguna Hills CA, US
Martha Garrity - San Clemente CA, US
Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE
International Classification:

G01N 33/533
G01N 33/532
G01N 21/76
G01N 33/53
C07D 219/02
C07D 219/04
US Classification:

436546, 436544, 436172, 435 71, 546102, 546104
Abstract:

In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached to an antibody at higher loading before precipitation and aggregation problems are encountered. Additional compounds described herein contain linkers derived from short peptides and tetraethylene oxide which increase aqueous solubility due to hydrogen bonding with water molecules. The present invention also embraces reagents for multiple acridinium labeling for signal amplification composed of a peptide bearing several acridinium esters with sulfonate groups at regularly spaced intervals for increased solubility. The invention also embraces assays employing the above-described compounds.

Compositions And Methods For Detecting Reverse Transcriptase In A Sample
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US Patent:

20050147965, Jul 7, 2005
Filed:

Dec 31, 2003
Appl. No.:

10/750092
Inventors:

Zhandong Zhong - Thousand Oaks CA, US
Martha Garrity - San Clemente CA, US
International Classification:

C12Q001/70
C12Q001/68
US Classification:

435005000, 435006000
Abstract:

The present invention provides methods for detecting the presence and enzymatic activity of reverse transcriptase (RT) in a sample. The methods generally involve conducting a reverse transcriptase PCR assay in the presence of labeled deoxynucleotides. The deoxynucleotides are incorporated into a molecular structure or complex containing the RNA template and the extending cDNA primer. In one embodiment the deoxynucleotides are labeled with a detectable moiety. A capture moiety can also be included to immobilize the complex on a surface after completion of the reaction and facilitates detection of the molecular structure, and therefore the presence of reverse transcriptase. In one embodiment the detectable moiety is a chemiluminescent moiety, such as an acridinium dye, and the assay is determined by stimulating chemiluminescence from the detectable moiety and detecting light emitted. In various embodiments the assays are also useful for determining the sub-type of reverse transcriptase present in a sample, or for screening for anti-retroviral lead compounds. Also disclosed are kits for conducting the assay.