Nozer Mehta - Randolph NJ, US Angelo Consalvo - Monroe NY, US Martha Ray - Nutley NJ, US Christopher Meenan - Lincoln Park NJ, US
Assignee:
Unigene Laboratories, Inc.
International Classification:
C12P021/02 C12P021/06 C12N001/21
US Classification:
435/069100, 435/069400, 435/252330
Abstract:
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with novel vectors, a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special vectors are provided which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with novel vectors, a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special vectors are provided which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.
Oral Delivery Of Peptides Using Enzyme-Cleavable Membrane Translocators
William Stern - Tenafly NJ, US Nozer Mehta - Randolph NJ, US Martha Ray - Nutley NJ, US
Assignee:
Unigene Laboratories Inc.
International Classification:
C12Q001/70 A61K039/12 A61K039/21
US Classification:
424/208100, 424/204100, 435/005000, 424/186100
Abstract:
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the active peptide linked to a membrane translocator which is capable of being at least partially cleaved in vivo by an enzyme. The composition includes an acid-resistant protective vehicle which transports components of the invention through the stomach and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
Nozer Mehta - Randolph NJ, US Angelo Consalvo - Monroe NY, US Martha Ray - Nutley NJ, US Christopher Meenan - Lincoln Park NJ, US
Assignee:
Unigene Laboratories, Inc.
International Classification:
C12P021/02 C12N005/06
US Classification:
435/069100, 435/320100, 435/325000
Abstract:
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with novel vectors, a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special vectors are provided which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.
Bacterial Host Cell For The Direct Expression Of Peptides
Nozer Mehta - Randolph NJ, US Angelo Consalvo - Monroe NY, US Martha Ray - Nutley NJ, US Christopher Meenan - Lincoln Park NJ, US
International Classification:
C12N015/74 C12N001/20
US Classification:
435069400, 435252330, 435488000
Abstract:
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special universal cloning vectors are provided for the preparation of expression vectors which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.
Bacterial Host Cell For The Direct Expression Of Peptides
Nozer Mehta - Randolph NJ, US Angelo Consalvo - Monroe NY, US Martha Ray - Nutley NJ, US Christopher Meenan - Lincoln Park NJ, US
International Classification:
C12N 5/02
US Classification:
435252330
Abstract:
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special universal cloning vectors are provided for the preparation of expression vectors which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.
Bacterial Host Cell For The Direct Expression Of Peptides
Nozer Mehta - Randolph NJ, US Angelo Consalvo - Monroe NY, US Martha Ray - Nutley NJ, US Christopher Meenan - Lincoln Park NJ, US
International Classification:
C12P 21/04 C12N 1/20
US Classification:
435069100, 435252330
Abstract:
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special universal cloning vectors are provided for the preparation of expression vectors which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.
Bacterial Host Cell For The Direct Expression Of Peptides
Nozer Mehta - Randolph NJ, US Angelo Consalvo - Monroe NY, US Martha Ray - Nutley NJ, US Christopher Meenan - Lincoln Park NJ, US
International Classification:
C12N 1/20
US Classification:
435252300
Abstract:
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special universal cloning vectors are provided for the preparation of expression vectors which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.
Name / Title
Company / Classification
Phones & Addresses
Martha Ray
Delicious Mexican Eatery, Inc. Caterers
11335 Montwood, Ste. A-3, El Paso, TX 79936 9158571396, 9158571394
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