Martha J Ray

US Patent:

20030118610, Jun 26, 2003

Filed:

Nov 29, 2001

Appl. No.:

09/997465

Inventors:

William Stern - Tenafly NJ, US
Nozer Mehta - Randolph NJ, US
Martha Ray - Nutley NJ, US

Assignee:

Unigene Laboratories Inc.

International Classification:

C12Q001/70
A61K039/12
A61K039/21

US Classification:

424/208100, 424/204100, 435/005000, 424/186100

Abstract:

Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine in addition to having the active peptide linked to a membrane translocator which is capable of being at least partially cleaved in vivo by an enzyme. The composition includes an acid-resistant protective vehicle which transports components of the invention through the stomach and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.