Martin J Charles

US Patent:

58637869, Jan 26, 1999

Filed:

Jun 6, 1995

Appl. No.:

8/465982

Inventors:

Marc Feldmann - Hammersmith, GB
Patrick William Gray - Bothell WA
Martin John Charles Turner - Ann Arbor MI
Fionula Mary Brennan - Hammersmith, GB

Assignee:

The Mathilda and Terence Kennedy Institute of Rheumatology - London

International Classification:

C12N 510
C12N 1512
C12N 1562

US Classification:

4352523

Abstract:

A DNA molecule is provided which encodes a polypeptide which is capable of binding human TNF. alpha. and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the 55 kD and 75 kD receptors for human TNF. alpha. The ability of the polypeptide to bind to TNF. alpha. means that it can be used for treating diseases mediated by TNF. alpha. activity, such as rheumatoid arthritis.