Martin M Koocher from 90 Middle St, Lexington, MA 02421, age 94, Phone: 7818624163

Methods And Apparatus For Detecting An Analyte Of Interest Capable Of Being Converted Into A Carbonyl-Containing Composition
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US Patent:

48164143, Mar 28, 1989
Filed:

Oct 2, 1987
Appl. No.:

7/105138
Inventors:

Martin Koocher - Lexington MA
Nathan O. Siemers - Allston MA
Assignee:

Crystal Diagnostics, Inc. - Woburn MA
International Classification:

G01N 110
G01N 2100
US Classification:

436 85
Abstract:

The present invention provides unique methods and apparatus for the detection of an analyte of interest in a fluid sample by selective oxidation of the analyte into a carbonyl-containing compound followed by the controlled formation and growth of optically visible crystals as a qualitative and quantitative measure of the analyte. Epoxides, alcohols, olefins, arylalkanes and alkyl halides are among the many different classes or chemical entities which can be selectively detected in the concomittant presence or absence of other substances within the test sample.

Film Badge For Determining Carbonyl Compounds
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US Patent:

43805876, Apr 19, 1983
Filed:

Aug 20, 1981
Appl. No.:

6/294584
Inventors:

Martin Koocher - Lexington MA
Assignee:

Arthur D. Little, Inc. - Cambridge MA
International Classification:

G01N 2175
G01N 3100
US Classification:

436128
Abstract:

Method for the determination of fluidic-contained aldehydes. The method comprises bringing into contact said aldehyde and a chemically inert substrate having adhered to the surface thereof a substantially monodisperse system of particles of a derivatizing agent for the aldehydes thereby forming nucleating crystals; treating said nucleating crystals with a metastable supersaturated solution in which said nucleating crystals can grow; growing said nucleating crystals to form an optically measurable film of crystals; and optically measuring said film of crystals to determine the concentration of fluidic-contained aldehydes.

Binding Assays Involving Formation And Detection Of Light Scattering Crystals
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US Patent:

47270241, Feb 23, 1988
Filed:

May 12, 1986
Appl. No.:

6/862072
Inventors:

Martin Koocher - Lexington MA
Alan Burg - West Newton MA
International Classification:

G01N 3353
G01N 33537
G01N 2100
G01N 2147
US Classification:

435 7
Abstract:

A methodology for the detection of an analyte of interest in a fluid sample through the formation, growth, and optical detection of light scattering crystals. The methodology provides for direct assay and competitive binding assay protocols using pairs of specifically binding compositions and novel innovations in crystal growth technology to provide an analytical method which is useful in immunodiagnostic, environmental, and biochemical applications. The methodology and test kit apparatus provides rapid, reproducible, and accurate data and is sensitive for the detection of an analyte of interest present in the nanogram per milliliter range.

Assays For Qualitative And Quantitative Detection Of Organic And Inorganic Analytes Of Diverse Chemical Classes Via The Selective Formation And Growth Of Light Scattering Crystals
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US Patent:

49525131, Aug 28, 1990
Filed:

Oct 24, 1988
Appl. No.:

7/261730
Inventors:

Martin Koocher - Lexington MA
Assignee:

Crystal Diagnostics, Inc. - Woburn MA
International Classification:

G01N 3300
US Classification:

436 36
Abstract:

The present invention provides a general assay methodology suitable for the detection of organic analytes which are neither aldehydes nor ketones and for inorganic substances. The methodology utilizes prepared sensitized films of derivatizing agents and specific developer solutions for the selective and controlled formation of light scattering crystals whose presence serves as a qualitative and/or quantitative measure of the individual analyte of interest in the sample.

Martin M Koocher