Martin C Newman

US Patent:

20110172295, Jul 14, 2011

Filed:

Apr 6, 2009

Appl. No.:

12/937194

Inventors:

Scott M. Hammond - Pittsboro NC, US
Martin A. Newman - Chapel Hill NC, US
J. Michael Thomson - Nashville TN, US

Assignee:

THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL - Chapel Hill NC

International Classification:

A61K 31/7088
C12N 5/10
C12N 5/071
C12N 1/00
C12N 15/63
C07H 21/02
A61P 35/00
A61K 48/00

US Classification:

514 44 R, 435325, 435375, 435377, 435419, 435243, 4353201, 536 241

Abstract:

Provided herein are methods and compositions for the regulation of microRNA processing. The invention presents methods for inhibiting the activity of a Lin-28-like polypeptide and methods for treating a subject with cancer comprising administering to a subject with cancer a compound that inhibits the activity of a Lin-28-like polypeptide. Compositions comprise isolated polynucleotides and expression cassettes comprising the same that promote the processing of at least one of a regulated primary microRNA transcript by Drosha and a regulated precursor microRNA by Dicer when introduced into or expressed in a cell. Compositions and methods are also provided for the selective suppression of target polynucleotides by a microRNA based on the level of expression of a Lin-28-like polypeptide within a cell.

US Patent:

39944930, Nov 30, 1976

Filed:

Oct 23, 1975

Appl. No.:

5/624876

Inventors:

Martin Newman - Hicksville NY

Assignee:

The Raymond Lee Organization, Inc. - New York NY

International Classification:

A63B 7114

US Classification:

273 54B

Abstract:

A bowling accessory device for preventing two inner sections of a bowling finger from assuming a straight line comprises a strip-like member with a first ring-like member affixed to the member at a first end thereof and removably accommodating a section of a bowling finger. A second ring-like member is affixed to the second opposite end of the strip-like member and removably accommodates next-adjacent section of the bowling finger. An adjusting member adjustably affixed to the second ring-like member selectively varies the distance between the first and second ring-like members at their sides opposite the strip-like member thereby preventing the sections of the finger in the ring-like members from assuming a straight position.

US Patent:

D3446760, Mar 1, 1994

Filed:

Sep 6, 1991

Appl. No.:

7/756777

Inventors:

Martin Newman - New Rochelle NY

Assignee:

Gruen Marketing Corporation - Exeter PA

US Classification:

D 9430

US Patent:

D3569713, Apr 4, 1995

Filed:

Sep 6, 1991

Appl. No.:

7/756149

Inventors:

Martin Newman - New Rochelle NY

Assignee:

Gruen Marketing Corporation - Exeter PA

US Classification:

D10128