Martin Newman

US Patent:

20110172295, Jul 14, 2011

Filed:

Apr 6, 2009

Appl. No.:

12/937194

Inventors:

Scott M. Hammond - Pittsboro NC, US
Martin A. Newman - Chapel Hill NC, US
J. Michael Thomson - Nashville TN, US

Assignee:

THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL - Chapel Hill NC

International Classification:

A61K 31/7088
C12N 5/10
C12N 5/071
C12N 1/00
C12N 15/63
C07H 21/02
A61P 35/00
A61K 48/00

US Classification:

514 44 R, 435325, 435375, 435377, 435419, 435243, 4353201, 536 241

Abstract:

Provided herein are methods and compositions for the regulation of microRNA processing. The invention presents methods for inhibiting the activity of a Lin-28-like polypeptide and methods for treating a subject with cancer comprising administering to a subject with cancer a compound that inhibits the activity of a Lin-28-like polypeptide. Compositions comprise isolated polynucleotides and expression cassettes comprising the same that promote the processing of at least one of a regulated primary microRNA transcript by Drosha and a regulated precursor microRNA by Dicer when introduced into or expressed in a cell. Compositions and methods are also provided for the selective suppression of target polynucleotides by a microRNA based on the level of expression of a Lin-28-like polypeptide within a cell.