Martin P Sorette

US Patent:

20080044843, Feb 21, 2008

Filed:

Dec 21, 2006

Appl. No.:

11/614893

Inventors:

Lorah Perlee - Wilton CT, US
Martin Sorette - Delmar NY, US
Velizar Tchernev - Sofia, BG
Stephen Kingsmore - Santa Fe NM, US

International Classification:

G01N 33/50
C12Q 1/34
C12Q 1/37

US Classification:

435024000, 435018000, 436087000

Abstract:

Detection of expression of biomarkers (e.g., protein analytes) whose regulation is perturbed in COPD patients can be used to diagnose COPD, to confirm a diagnosis of COPD, and to assess or prognose progression of COPD. Test substances can be screened for the ability to affect levels of protein analyte expression, thereby identifying potential anti-COPD drugs.

US Patent:

20110159530, Jun 30, 2011

Filed:

Jun 10, 2009

Appl. No.:

12/997247

Inventors:

Kenneth A. Pass - Glenmont NY, US
Martin Sorette - Amsterdam NY, US
Barbara Shepard - Albany NY, US

International Classification:

C12Q 1/28
G01N 33/72

US Classification:

435 28, 436501

Abstract:

Methods are provided for simultaneously measuring hematocrit (hct) level and the concentration of a biomarker in a blood specimen. Thus, serum biomarker concentrations can be more accurately measured. The methods are particularly useful for newborn screening programs.

US Patent:

61141739, Sep 5, 2000

Filed:

Apr 3, 1997

Appl. No.:

8/833033

Inventors:

David Zelmanovic - Monsey NY
Lynn Paseltiner - Monroe NY
Martin Sorette - Brighton MA

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

G01N 3348

US Classification:

436 63

Abstract:

The invention provides a very fast and reliable method and reagent composition for determining reticulocyte and erythrocyte counts, identification and characterization, as well as platelet counts, in a whole blood sample using fully automated hematology analyzers. The reagent composition includes a zwitterionic surfactant as sphering agent for reticulocytes and erythrocytes, an organic cationic dye, e. g. , Oxazine 750, for staining the reticulocytes, and buffer solution components for maintaining a reagent pH of about 7. 2 to 7. 8, and an osmolarity of about 292. +-. 5. On the basis of the particular pH, ionic strength, and dye concentration, the reagent composition of the present method improves upon previous methods, thus allowing fully automated blood sample analyses to be completed in less than about 30 seconds, with only about a 20 second incubation of sample in the reagent solution before analysis. With such a rapid incubation time, the reagent mixture is passed through the sensing region of a flow cytometer, and the light scattered and absorbed by each cell is rapidly measured to provide accurate cell determinations and counts. The volume and hemoglobin concentration and content of each erythrocyte or reticulocyte are determined.

US Patent:

62853775, Sep 4, 2001

Filed:

Jun 26, 1997

Appl. No.:

8/882974

Inventors:

Albert Greenbaum - Spring Valley NY
Martin Sorette - Ossining NY
Jolanta Kunicka - Ridgewood NJ
Gena Fischer - Harrington Park NJ

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

G06T 1120
A61B 500

US Classification:

345441

Abstract:

A system and method for displaying parameters in a smoothed normalized star diagram where parameters are received from a medical laboratory instrument and processed. The processing includes calculating a normalized parameter value for each parameter using a predetermined mean and standard deviation and scaling the resulting normalized parameter value using a range restricting function. Each scaled parameter is assigned to a spoke and rays are drawn between adjacent spokes at a small angular interval. The ends of the rays are then joined by line segments, thereby constructing a smooth overall diagram.