VASSILIOS PAPADOPOULOS - NORTH POTOMAC MD, US MARTINE CULTY - NORTH POTOMAC MD, US
International Classification:
C12Q001/68 A61K039/395 A61K048/00
US Classification:
424/143100, 514/044000, 435/006000
Abstract:
The expression and subcellular localization of peripheral-type benzodiazepine receptors (PBR) is shown in this application to correlate with the metastatic potential of cells, and increased cell proliferation. Inhibition of PBR expression, function or stability results in a decrease in cell proliferation. Compositions and methods for regulating and/or monitoring PBR and its expression are useful for the detection, diagnosis, prognosis and treatment of solid tumors, in particular, breast cancer.
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