Martine Aliana Rothblatt

US Patent:

8609728, Dec 17, 2013

Filed:

Mar 14, 2011

Appl. No.:

13/047033

Inventors:

Martine A. Rothblatt - Satellite Beach FL, US
Lewis J. Rubin - LaJolla CA, US

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/19

US Classification:

514569, 5142621, 514269

Abstract:

One embodiment relates to a method of treating pulmonary hypertension based upon co-administering to a subject in need thereof a pharmaceutically effective amount of an oral therapeutic agent for treating pulmonary hypertension and a pharmaceutically effective amount of an inhaled therapeutic agent for treating pulmonary hypertension. The benefit of the co-administration of these agents is to eliminate or reduce one or more side effects associated with mono-therapy of either agent, as well as one or more side effects associated with other administration routes such as subcutaneous or intravenous administration.

US Patent:

20120010159, Jan 12, 2012

Filed:

Jul 5, 2011

Appl. No.:

13/176085

Inventors:

Martine Rothblatt - Satellite Beach FL, US
Martin Auster - Silver Spring MD, US

International Classification:

A61K 38/06
A61K 31/415
A61K 31/42
A61K 31/196
A61P 19/02
A61K 38/05
A61K 31/661
A61K 38/07
A61P 29/00
A61K 31/365
A61K 31/216

US Classification:

514 219, 514473, 514406, 514378, 514567, 514510, 514 2191, 514114

Abstract:

The present invention is directed to compositions and methods for pain management, and for treating inflammation or an inflammation-associated disorder in a subject comprising administering to the subject a therapeutically effective amount of a COX-2 inhibitor and a therapeutically effective amount of a prostacyclin analog, such as treprostinil, a pharmaceutically acceptable salt thereof, or a treprostinil derivative described herein.