Mary Janet Blake

US Patent:

7105186, Sep 12, 2006

Filed:

Sep 9, 2002

Appl. No.:

10/238647

Inventors:

Charles J. Arntzen - Ithaca NY, US
Mary E. Blake - Tucson AZ, US
Jordan U. Gutterman - Houston TX, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

A61K 35/78
C12N 5/10
C12N 5/00
C12P 19/44
A01N 43/04

US Classification:

424757, 435419, 435420, 435 74, 514 25

Abstract:

The invention provides saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

US Patent:

7670632, Mar 2, 2010

Filed:

Dec 6, 2005

Appl. No.:

11/295189

Inventors:

Charles J. Arntzen - Ithaca NY, US
Mary E. Blake - Tucson AZ, US
Jordan U. Gutterman - Houston TX, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

A61K 35/78
A61P 9/10

US Classification:

424757, 514821

Abstract:

The invention provides saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

US Patent:

7985435, Jul 26, 2011

Filed:

Jan 15, 2010

Appl. No.:

12/688651

Inventors:

Charles J. Arntzen - Ithaca NY, US
Mary E. Blake - Tucson AZ, US
Jordan U. Gutterman - Houston TX, US
Joseph J. Hoffmann - Tucson AZ, US
Gamini S. Jayatilake - Broomfield CO, US
David T. Bailey - Boulder CO, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

A61K 31/704
A61K 31/7034
A61K 36/38
C07H 15/256
A61P 35/00

US Classification:

424757, 536 181, 514 25, 514 33

Abstract:

The invention provides saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

US Patent:

8324177, Dec 4, 2012

Filed:

Jun 14, 2011

Appl. No.:

13/160144

Inventors:

Charles J. Arntzen - Ithaca NY, US
Mary E. Blake - Tucson AZ, US
Jordan U. Gutterman - Houston TX, US
Joseph J. Hoffmann - Tucson AZ, US
Gamini S. Jayatilake - Broomfield CO, US
David T. Bailey - Boulder CO, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

A61K 31/70
C07H 15/24

US Classification:

514 33, 536 181

Abstract:

The invention provides saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

US Patent:

6444233, Sep 3, 2002

Filed:

May 19, 1999

Appl. No.:

09/314691

Inventors:

Charles J. Arntzen - Ithaca NY
Mary E. Blake - Tucson AZ
Jordan U. Gutterman - Houston TX
Joseph J. Hoffmann - Tucson AZ
Gamini S. Jayatilake - Broomfield CO
David T. Bailey - Boulder CO

Assignee:

Research Development Foundation - Carson City NV

International Classification:

A61K 3578

US Classification:

424725, 514183

Abstract:

The invention provides novel saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.