Mary K Hagler

US Patent:

20040047890, Mar 11, 2004

Filed:

Mar 27, 1998

Appl. No.:

09/049865

Inventors:

COLLIN J. WEBER - ATLANTA GA, US
MARY K. HAGLER - LOGANVILLE GA, US
PETER S. LINSLEY - SEATTLE WA, US
JUDITH A. KAPP - ATLANTA GA, US
SUSAN A. SAFLEY - DECATUR GA, US

International Classification:

A61K045/00
A61K039/395

US Classification:

424/423000, 424/093700, 424/131100

Abstract:

This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune-system costimulation event in an amount effective to inhibit the subject's immune system from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune-system costimulation event is CTLA4. Also provided by this invention is a method of treating diabetes in a subject which comprises: a) containing viable insulin-producing cells, or tissue comprising such cells, within a device comprising a semipermeable membrane; b) transplanting an effective amount of such contained viable insulin-producing cells into the subject; and c) treating the subject with an effective amount of a substance which inhibits an immune-system costimulation event.

Address:

6910 Roundtree St, Shawnee, KS 66226

Phone:

8172380842

VIN:

WDBWK54F57F146285

Make:

MERCEDES BENZ

Model:

SLK CLASS

Year:

2007