Mary Ann Monroe

US Patent:

20170327562, Nov 16, 2017

Filed:

Aug 2, 2017

Appl. No.:

15/666709

Inventors:

- College Station TX, US
Magnus Hook - Houston TX, US
Mariah S. Hahn - College Station TX, US
Elizabeth M. Cosgriff-Hernandez - College Station TX, US
Neungseon Seo - Carmel IN, US
Marvin Xuejun Xu - Missouri City TX, US
Jose J. Rivera - Humble TX, US
Mary Beth Monroe - Houston TX, US

International Classification:

C07K 14/78
A61L 33/06
A61L 26/00
A61L 26/00
A61L 26/00
A61L 33/00
A61L 27/48
A61L 27/50
A61L 27/52
A61L 27/54
A61L 26/00
C08G 65/333
A61L 27/26

Abstract:

The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure.