Mary Murray

US Patent:

7202226, Apr 10, 2007

Filed:

Oct 23, 2001

Appl. No.:

10/001563

Inventors:

Mary Theresa Murray - Grosse Pointe MI, US
Scott Alexander Dulchavsky - Grosse Pointe Park MI, US

Assignee:

Detroit R & D - Detroit MI

International Classification:

A61K 48/00

US Classification:

514 44

Abstract:

There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting transient protein synthesis in cells by increasing protein synthesis of growth factors from endogenous cellular mRNA and exogenous mRNA delivered to the cells. A treatment for transiently increasing protein production in cells, said treatment comprising mRNA functionally related to protein production is also provided. There is provided a method of augmenting wound healing by delivering mRNA functionally related to wound healing. Further provided is a therapeutic for transiently increasing protein synthesis in cells, said therapeutic comprising mRNA related to protein production.

US Patent:

20040216175, Oct 28, 2004

Filed:

Feb 17, 2004

Appl. No.:

10/780339

Inventors:

Hyesook Kim - Bloomfield Hills MI, US
Mary Murray - Grosse Pointe MI, US
Raymond Novak - Orchard Lake MI, US

International Classification:

C12Q001/68
A01K067/00

US Classification:

800/008000, 435/004000, 435/006000

Abstract:

A screen for detecting, identifying, and characterizing chemicals as toxicants is based on the affect of the chemical on gene expression in animal cleavage stage embryos. A microarray screen for detecting and measuring the affects of chemicals on gene expression in animal cleavage stage embryos. A screen for detecting, identifying, and characterizing chemicals as toxicants based on the common or differential affects on gene expression in animal cleavage stage embryos and neurulation stage embryos. Markers of chemical exposure and teratogenesis identified using the screen disclosed herein. A treatment that enables the transfer of biotinylated PCR products or DNA to a membrane following gel electrophoresis by depurinating the PCR or DNA products and denaturing the PCR products or DNA.

US Patent:

20070149475, Jun 28, 2007

Filed:

Feb 28, 2007

Appl. No.:

11/680243

Inventors:

Mary Murray - Grosse Pointe MI, US
Scott Dulchavsky - Grosse Pointe Park MI, US

International Classification:

A61K 48/00
C12N 15/09

US Classification:

514044000, 435455000

Abstract:

There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting transient protein synthesis in cells by increasing protein synthesis of growth factors from endogenous cellular mRNA and exogenous mRNA delivered to the cells. A treatment for transiently increasing protein production in cells, said treatment comprising mRNA functionally related to protein production is also provided. There is provided a method of augmenting wound healing by delivering mRNA functionally related to wound healing. Further provided is a therapeutic for transiently increasing protein synthesis in cells, said therapeutic comprising mRNA related to protein production.

US Patent:

20080145858, Jun 19, 2008

Filed:

Dec 26, 2007

Appl. No.:

11/964117

Inventors:

Hyesook Kim - Bloomfield Hills MI, US
Mary Murray - Grosse Pointe MI, US
Raymond F. Novak - Orchard Lake MI, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

A screen for detecting, identifying, and characterizing chemicals as toxicants is based on the affect of the chemical on gene expression in animal cleavage stage embryos. A microarray screen for detecting and measuring the affects of chemicals on gene expression in animal cleavage stage embryos. A screen for detecting, identifying and characterizing chemicals as toxicants based on the common or differential affects on gene expression in animal cleavage stage embryos and neurulation stage embryos. Markers of chemical exposure and teratogenesis identified using the screen disclosed herein. A treatment that enables the transfer of biotinylated PCR products or DNA to a membrane following gel electrophoresis by depurinating the PCR or DNA products and denaturing the PCR products or DNA.